Role of RLIP76 in doxorubicin resistance in lung cancer (review)

Rit Vatsyayan, Pankaj Chaudhary, Poorna Chandra Rao Lelsani, Preeti Singhal, Yogesh C. Awasthi, Sanjay Awasthi, Sharad S. Singhal

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

Lung cancer is still a major cause of cancer deaths in spite of considerable efforts in its systemic therapy. Chemotherapy, along with local irradiation is frequently employed but as a palliative therapy. Inherent and acquired resistance in NSCLC and SCLC towards chemotherapeutic agents further makes chemotherapy an incommodious problem. The resistance mechanisms responsible for inherent DOX-resistance of NSCLC and acquired DOX-resistance in SCLC have been the subject of numerous investigations. This review will focus on the recent studies done for understanding the mechanism(s) of inherent and acquired resistance in NSCLC and SCLC and how these can be exploited for the future development of more effective novel biologic agents for the treatment of lung cancer.

Original languageEnglish
Pages (from-to)1505-1511
Number of pages7
JournalInternational journal of oncology
Volume34
Issue number6
DOIs
StatePublished - 3 Jul 2009

Fingerprint

Doxorubicin
Lung Neoplasms
Drug Therapy
Biological Factors
Palliative Care
Cause of Death
Therapeutics
Neoplasms

Keywords

  • Cancer
  • Doxorubicin
  • Drug-resistance
  • Glutathione conjugate transport
  • PKCα
  • RLIP76

Cite this

Vatsyayan, R., Chaudhary, P., Lelsani, P. C. R., Singhal, P., Awasthi, Y. C., Awasthi, S., & Singhal, S. S. (2009). Role of RLIP76 in doxorubicin resistance in lung cancer (review). International journal of oncology, 34(6), 1505-1511. https://doi.org/10.3892/ijo_00000279
Vatsyayan, Rit ; Chaudhary, Pankaj ; Lelsani, Poorna Chandra Rao ; Singhal, Preeti ; Awasthi, Yogesh C. ; Awasthi, Sanjay ; Singhal, Sharad S. / Role of RLIP76 in doxorubicin resistance in lung cancer (review). In: International journal of oncology. 2009 ; Vol. 34, No. 6. pp. 1505-1511.
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Vatsyayan, R, Chaudhary, P, Lelsani, PCR, Singhal, P, Awasthi, YC, Awasthi, S & Singhal, SS 2009, 'Role of RLIP76 in doxorubicin resistance in lung cancer (review)', International journal of oncology, vol. 34, no. 6, pp. 1505-1511. https://doi.org/10.3892/ijo_00000279

Role of RLIP76 in doxorubicin resistance in lung cancer (review). / Vatsyayan, Rit; Chaudhary, Pankaj; Lelsani, Poorna Chandra Rao; Singhal, Preeti; Awasthi, Yogesh C.; Awasthi, Sanjay; Singhal, Sharad S.

In: International journal of oncology, Vol. 34, No. 6, 03.07.2009, p. 1505-1511.

Research output: Contribution to journalReview article

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AU - Chaudhary, Pankaj

AU - Lelsani, Poorna Chandra Rao

AU - Singhal, Preeti

AU - Awasthi, Yogesh C.

AU - Awasthi, Sanjay

AU - Singhal, Sharad S.

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KW - Doxorubicin

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Vatsyayan R, Chaudhary P, Lelsani PCR, Singhal P, Awasthi YC, Awasthi S et al. Role of RLIP76 in doxorubicin resistance in lung cancer (review). International journal of oncology. 2009 Jul 3;34(6):1505-1511. https://doi.org/10.3892/ijo_00000279