Role of RAGE in Alzheimer’s Disease

Zhiyou Cai, Nannuan Liu, Chuanling Wang, Biyong Qin, Yingjun Zhou, Ming Xiao, Liying Chang, Liang Jun Yan, Bin Zhao

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

Receptor for advanced glycation end products (RAGE) is a receptor of the immunoglobulin super family that plays various important roles under physiological and pathological conditions. Compelling evidence suggests that RAGE acts as both an inflammatory intermediary and a critical inducer of oxidative stress, underlying RAGE-induced Alzheimer-like pathophysiological changes that drive the process of Alzheimer’s disease (AD). A critical role of RAGE in AD includes beta-amyloid (Aβ) production and accumulation, the formation of neurofibrillary tangles, failure of synaptic transmission, and neuronal degeneration. The steady-state level of Aβ depends on the balance between production and clearance. RAGE plays an important role in the Aβ clearance. RAGE acts as an important transporter via regulating influx of circulating Aβ into brain, whereas the efflux of brain-derived Aβ into the circulation via BBB is implemented by LRP1. RAGE could be an important contributor to Aβ generation via enhancing the activity of β- and/or γ-secretases and activating inflammatory response and oxidative stress. However, sRAGE–Aβ interactions could inhibit Aβ neurotoxicity and promote Aβ clearance from brain. Meanwhile, RAGE could be a promoting factor for the synaptic dysfunction and neuronal circuit dysfunction which are both the material structure of cognition, and the physiological and pathological basis of cognition. In addition, RAGE could be a trigger for the pathogenesis of Aβ and tau hyper-phosphorylation which both participate in the process of cognitive impairment. Preclinical and clinical studies have supported that RAGE inhibitors could be useful in the treatment of AD. Thus, an effective measure to inhibit RAGE may be a novel drug target in AD.

Original languageEnglish
Pages (from-to)483-495
Number of pages13
JournalCellular and Molecular Neurobiology
Volume36
Issue number4
DOIs
StatePublished - 1 May 2016

Fingerprint

Alzheimer Disease
Cognition
Brain
Oxidative Stress
Advanced Glycosylation End Product-Specific Receptor
Amyloid Precursor Protein Secretases
Neurofibrillary Tangles
Amyloid
Synaptic Transmission
Immunoglobulins
Phosphorylation
Pharmaceutical Preparations

Keywords

  • Alzheimer’s disease
  • Beta-amyloid
  • Cognitive impairment
  • Receptor for advanced glycation end products
  • Tau hyperphosphorylation

Cite this

Cai, Z., Liu, N., Wang, C., Qin, B., Zhou, Y., Xiao, M., ... Zhao, B. (2016). Role of RAGE in Alzheimer’s Disease. Cellular and Molecular Neurobiology, 36(4), 483-495. https://doi.org/10.1007/s10571-015-0233-3
Cai, Zhiyou ; Liu, Nannuan ; Wang, Chuanling ; Qin, Biyong ; Zhou, Yingjun ; Xiao, Ming ; Chang, Liying ; Yan, Liang Jun ; Zhao, Bin. / Role of RAGE in Alzheimer’s Disease. In: Cellular and Molecular Neurobiology. 2016 ; Vol. 36, No. 4. pp. 483-495.
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Cai, Z, Liu, N, Wang, C, Qin, B, Zhou, Y, Xiao, M, Chang, L, Yan, LJ & Zhao, B 2016, 'Role of RAGE in Alzheimer’s Disease', Cellular and Molecular Neurobiology, vol. 36, no. 4, pp. 483-495. https://doi.org/10.1007/s10571-015-0233-3

Role of RAGE in Alzheimer’s Disease. / Cai, Zhiyou; Liu, Nannuan; Wang, Chuanling; Qin, Biyong; Zhou, Yingjun; Xiao, Ming; Chang, Liying; Yan, Liang Jun; Zhao, Bin.

In: Cellular and Molecular Neurobiology, Vol. 36, No. 4, 01.05.2016, p. 483-495.

Research output: Contribution to journalReview article

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Cai Z, Liu N, Wang C, Qin B, Zhou Y, Xiao M et al. Role of RAGE in Alzheimer’s Disease. Cellular and Molecular Neurobiology. 2016 May 1;36(4):483-495. https://doi.org/10.1007/s10571-015-0233-3