Role of ApoE-ε4 Genotype in Gait and Balance in Older Adults: A Pilot Study

John R. Biggan, Wyn E. Taylor, Kamiah Moss, Larry Adumatioge, Vale Shannon, Robert Joseph Gatchel, Christopher T. Ray

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Falls are common and costly in older adults. Risk factors include deficits in gait and postural control, both of which are linked to cognitive impairments. These cognitive impairments may be attributed to a genetic predisposition. A previous study found that a genetic risk factor related to Alzheimer's disease (the ApoE-ε4 genetic variant) is also related to gait speed decline in older adults. No research has attempted to assess the impact of this variant on postural control in older adults. The purpose of this pilot study was to replicate the gait findings and extend these to measures of balance in older adults. Forty-six older adults, without a history of neurological disorder, were genotyped and had their gait and postural control assessed. Surprisingly, analyses showed lowered double-stance time for carriers than noncarriers of the ε4 isoform. However, no significant differences were observed between carriers and noncarriers for any other comparisons, including postural control scores. Results suggest that the ε4 isoform may affect gait, but not postural control.

Original languageEnglish
Article numbere12061
JournalJournal of Applied Biobehavioral Research
Volume22
Issue number2
DOIs
StatePublished - 1 Jun 2017

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Apolipoproteins E
Gait
Genotype
Protein Isoforms
Genetic Predisposition to Disease
Nervous System Diseases
dementia
deficit
Research
Cognitive Dysfunction

Cite this

Biggan, J. R., Taylor, W. E., Moss, K., Adumatioge, L., Shannon, V., Gatchel, R. J., & Ray, C. T. (2017). Role of ApoE-ε4 Genotype in Gait and Balance in Older Adults: A Pilot Study. Journal of Applied Biobehavioral Research, 22(2), [e12061]. https://doi.org/10.1111/jabr.12061
Biggan, John R. ; Taylor, Wyn E. ; Moss, Kamiah ; Adumatioge, Larry ; Shannon, Vale ; Gatchel, Robert Joseph ; Ray, Christopher T. / Role of ApoE-ε4 Genotype in Gait and Balance in Older Adults : A Pilot Study. In: Journal of Applied Biobehavioral Research. 2017 ; Vol. 22, No. 2.
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Biggan, JR, Taylor, WE, Moss, K, Adumatioge, L, Shannon, V, Gatchel, RJ & Ray, CT 2017, 'Role of ApoE-ε4 Genotype in Gait and Balance in Older Adults: A Pilot Study', Journal of Applied Biobehavioral Research, vol. 22, no. 2, e12061. https://doi.org/10.1111/jabr.12061

Role of ApoE-ε4 Genotype in Gait and Balance in Older Adults : A Pilot Study. / Biggan, John R.; Taylor, Wyn E.; Moss, Kamiah; Adumatioge, Larry; Shannon, Vale; Gatchel, Robert Joseph; Ray, Christopher T.

In: Journal of Applied Biobehavioral Research, Vol. 22, No. 2, e12061, 01.06.2017.

Research output: Contribution to journalArticle

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Biggan JR, Taylor WE, Moss K, Adumatioge L, Shannon V, Gatchel RJ et al. Role of ApoE-ε4 Genotype in Gait and Balance in Older Adults: A Pilot Study. Journal of Applied Biobehavioral Research. 2017 Jun 1;22(2). e12061. https://doi.org/10.1111/jabr.12061