Ring closing metathesis for the formation of medium ring ethers: The total synthesis of (-)-isolaurallene

Michael T. Crimmins, Kyle Allen Emmitte, Allison L. Choy

Research output: Contribution to journalArticle

73 Scopus citations

Abstract

The total synthesis of the marine metabolite (-)-isolaurallene is described. Two approaches to the core nine-membered ether are presented both of which are based on a ring closing metathesis to close the cyclic ether.

Original languageEnglish
Pages (from-to)1817-1834
Number of pages18
JournalTetrahedron
Volume58
Issue number10
DOIs
StatePublished - 4 Mar 2002

Keywords

  • Asymmetric aldol
  • Asymmetric alkylation
  • Isolaurallene
  • Marine natural products
  • Metathesis
  • Oxonene

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