Reversed-phase high-performance liquid chromatography-thermospray mass spectrometry of alprenolol and its ketoxime analogues

Laszlo Prokai, Nicholas Bodor

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Thermospray mass spectrometric detection is applied for alprenolol and its isomeric (E and Z) ketoxime analogues separated by reversed-phase high-performance liquid chromatography. The thermospray process results in high-intensity [M+H]+ ion formation. This method of detection provides high level of molecular specificity, and offers advantages for the identification of the stereoisomeric oximes due to the unique fragmentation pattern of the spectra.

Original languageEnglish
Pages (from-to)474-479
Number of pages6
JournalJournal of Chromatography A
Volume541
Issue numberC
DOIs
StatePublished - 1991

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