Reversed-phase high-performance liquid chromatography of aryloxyalkylaminoketone-oximes is optimized by implementing bonded-phase (C8 and C18) column packings deactivated for basic compounds, and competing base as mobile phase additive. The retention of Z isomers is prolonged because of intramolecular hydrogen bonding. The selectivity coefficients for the separation of E and Z compounds is influenced by internal constraints and intramolecular interaction of polar functional groups.
|Number of pages||5|
|Journal||Journal of Chromatography A|
|State||Published - 1991|