Reversed-phase high-performance liquid chromatography of ketoxime analogues of β-adrenergic blockers

Laszlo Prokai, Antal Simay, Nicholas Bodor

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Reversed-phase high-performance liquid chromatography of aryloxyalkylaminoketone-oximes is optimized by implementing bonded-phase (C8 and C18) column packings deactivated for basic compounds, and competing base as mobile phase additive. The retention of Z isomers is prolonged because of intramolecular hydrogen bonding. The selectivity coefficients for the separation of E and Z compounds is influenced by internal constraints and intramolecular interaction of polar functional groups.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalJournal of Chromatography A
Volume541
Issue numberC
DOIs
StatePublished - 1 Jan 1991

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