Abstract
Reversed-phase high-performance liquid chromatography of aryloxyalkylaminoketone-oximes is optimized by implementing bonded-phase (C8 and C18) column packings deactivated for basic compounds, and competing base as mobile phase additive. The retention of Z isomers is prolonged because of intramolecular hydrogen bonding. The selectivity coefficients for the separation of E and Z compounds is influenced by internal constraints and intramolecular interaction of polar functional groups.
Original language | English |
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Pages (from-to) | 469-473 |
Number of pages | 5 |
Journal | Journal of Chromatography A |
Volume | 541 |
Issue number | C |
DOIs | |
State | Published - 1991 |