Abstract
Reversed-phase high-performance liquid chromatography of aryloxyalkylaminoketone-oximes is optimized by implementing bonded-phase (C8 and C18) column packings deactivated for basic compounds, and competing base as mobile phase additive. The retention of Z isomers is prolonged because of intramolecular hydrogen bonding. The selectivity coefficients for the separation of E and Z compounds is influenced by internal constraints and intramolecular interaction of polar functional groups.
| Original language | English |
|---|---|
| Pages (from-to) | 469-473 |
| Number of pages | 5 |
| Journal | Journal of Chromatography A |
| Volume | 541 |
| Issue number | C |
| DOIs | |
| State | Published - 1991 |