@article{e15a38fe51844af182689412f8844e89,
title = "Resolution of the conformational distribution and dynamics of a flexible molecule using frequency-domain fluorometry",
abstract = "We report the first resolution of both the conformational distribution and end-to-end diffusion coefficient of a flexible molecule. This molecular information was recovered using only the donor intensity decay in a single solvent at a single viscosity, as observed by the technique of frequency-domain fluorometry. This technique can be extended to measurements of structural fluctuations of biological macromolecules.",
keywords = "Conformational analysis, Fluorescence, Frequency-domain fluorometry, Molecular dynamics, Resonance energy transfer",
author = "Lakowicz, {Joseph R.} and J{\'o}zef Ku{\'s}ba and Wieslaw Wiczk and Ignacy GryczynSki and Henryk Szmacinski and Johnson, {Michael L.}",
note = "Funding Information: The work was supported by Grants GM 35154 from the NIH and DMB 8804939f rom the NSF, with support for instrumentation from NSF Grant DIR 8710401a nd DMB 8502835J.. R.L. and W.W. acknowledge support from the Medical Biotechnology Center of the University of Maryland and J.K. would like to acknowledge the Kosciuszko Foundation in New York for fellowship support which contributed to this researcha nd the Polish",
year = "1991",
month = jan,
doi = "10.1016/0301-4622(91)85008-E",
language = "English",
volume = "39",
pages = "79--84",
journal = "Biophysical Chemistry",
issn = "0301-4622",
publisher = "Elsevier",
number = "1",
}