Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment

Gillian Franklin; Homero Harari; Samavi Ahsan; Dhimiter Bello; David A. Sterling; Jonathan Nedrelow; Scott Raynaud; Swati Biswas; Youcheng Liu

doi:10.4137/EHI.S39149

Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment

Gillian Franklin, Homero Harari, Samavi Ahsan, Dhimiter Bello, David A. Sterling, Jonathan Nedrelow, Scott Raynaud, Swati Biswas, Youcheng Liu

Biostatistics & Epidemiology

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE^™. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4‘-MDI = 0.52 to 140.1 pg/mg) and (2,4‘-MDI = 0.01 to 4.48 pg/mg). The 4,4‘-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.

Original language	English
Journal	Environmental Health Insights
Volume	10
DOIs	https://doi.org/10.4137/EHI.S39149
State	Published - 2016

Keywords

asthma
isocyanates
medical devices and products
methylene diphenyl diisocyanate
neonatal exposure
skin sensitization

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10.4137/EHI.S39149

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@article{7897bb38f0cf4ada9be0874a2c140aa5,

title = "Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment",

abstract = "We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE{\texttrademark}. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4{\textquoteleft}-MDI = 0.52 to 140.1 pg/mg) and (2,4{\textquoteleft}-MDI = 0.01 to 4.48 pg/mg). The 4,4{\textquoteleft}-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.",

keywords = "asthma, isocyanates, medical devices and products, methylene diphenyl diisocyanate, neonatal exposure, skin sensitization",

author = "Gillian Franklin and Homero Harari and Samavi Ahsan and Dhimiter Bello and Sterling, {David A.} and Jonathan Nedrelow and Scott Raynaud and Swati Biswas and Youcheng Liu",

note = "Funding Information: This pilot study was supported by Cook Children's Medical Center's Clinical Scholars Award. We thank the NICU at Cook Children's Healthcare System for providing the devices and products to this study. We also thank Mr. Thomas Klingner at the Colormetric Laboratories, Inc. and Dr. Joyce Hood at Cook Children's Medical Center for technical assistance. Funding Information: This pilot study was supported by Cook Children's Medical Center's Clinical Scholars Award. We thank the NICU at Cook Children's Healthcare System for providing the devices and products to this study. We also thank Mr. Thomas Klingner at the Colormetric Laboratories, Inc. and Dr. Joyce Hood at Cook Children's Medical Center for technical assistance. Publisher Copyright: {\textcopyright} 2016 SAGE Publications.",

year = "2016",

doi = "10.4137/EHI.S39149",

language = "English",

volume = "10",

journal = "Environmental Health Insights",

issn = "1178-6302",

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TY - JOUR

T1 - Residual Isocyanates in Medical Devices and Products

T2 - A Qualitative and Quantitative Assessment

AU - Franklin, Gillian

AU - Harari, Homero

AU - Ahsan, Samavi

AU - Bello, Dhimiter

AU - Sterling, David A.

AU - Nedrelow, Jonathan

AU - Raynaud, Scott

AU - Biswas, Swati

AU - Liu, Youcheng

N1 - Funding Information: This pilot study was supported by Cook Children's Medical Center's Clinical Scholars Award. We thank the NICU at Cook Children's Healthcare System for providing the devices and products to this study. We also thank Mr. Thomas Klingner at the Colormetric Laboratories, Inc. and Dr. Joyce Hood at Cook Children's Medical Center for technical assistance. Funding Information: This pilot study was supported by Cook Children's Medical Center's Clinical Scholars Award. We thank the NICU at Cook Children's Healthcare System for providing the devices and products to this study. We also thank Mr. Thomas Klingner at the Colormetric Laboratories, Inc. and Dr. Joyce Hood at Cook Children's Medical Center for technical assistance. Publisher Copyright: © 2016 SAGE Publications.

PY - 2016

Y1 - 2016

N2 - We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE™. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4‘-MDI = 0.52 to 140.1 pg/mg) and (2,4‘-MDI = 0.01 to 4.48 pg/mg). The 4,4‘-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.

AB - We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU) stockroom inventory, polyurethane (PU) and PU foam (PUF) devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE™. Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI) species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4‘-MDI = 0.52 to 140.1 pg/mg) and (2,4‘-MDI = 0.01 to 4.48 pg/mg). The 4,4‘-MDI species had the highest measured concentration (280 pg/mg). Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.

KW - asthma

KW - isocyanates

KW - medical devices and products

KW - methylene diphenyl diisocyanate

KW - neonatal exposure

KW - skin sensitization

UR - http://www.scopus.com/inward/record.url?scp=85073260710&partnerID=8YFLogxK

U2 - 10.4137/EHI.S39149

DO - 10.4137/EHI.S39149

M3 - Article

AN - SCOPUS:85073260710

SN - 1178-6302

VL - 10

JO - Environmental Health Insights

JF - Environmental Health Insights

ER -

Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment

Abstract

Keywords

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