TY - JOUR
T1 - Reproductive history in mothers of children with neural tube defects
AU - Rivas, Fernando
AU - Dávalos, Ingrid P.
AU - Olivares, Norma
AU - Dávalos, Nory O.
AU - Pérez-Medina, Roberto
AU - Gómez-Partida, Guillermo
AU - Chakraborty, Ranajit
PY - 2000/1/1
Y1 - 2000/1/1
N2 - The reproductive history of 100 women with at least 1 child with a neural tube defect (NTD) has been studied. The data analyzed correspond to the period previous to their first visit to a genetic counseling service. A total of 204 pregnancies resulted in 205 outcomes. Of the 100 sibships, 14 (14%) had more than 1 affected member. The pregnancy was shorter than 28 weeks in 56/205 (27%) of the total outcomes. Of 104 evaluable previous outcomes, 34 corresponded to short pregnancies, positioned before an affected (23/60, 38%), a healthy (2/18, 11%), or an undiagnosed product (9/26, 35%). Short pregnancies subsequent to affected outcomes were also increased. The inter-gestational interval varied according to diagnosis: it was longer in the affected group than in the healthy one (0.1 > p > 0.05) and the subsequent intervals were shorter for the affected group (p < 0.05). An increased number of abortions adjacent to affected offspring and a changing fertility pattern, depending on the product diagnosis, point to an environmental etiological component in this high- risk NTD group of mothers. Copyright (C) 2000 S. Karger AG, Basel.
AB - The reproductive history of 100 women with at least 1 child with a neural tube defect (NTD) has been studied. The data analyzed correspond to the period previous to their first visit to a genetic counseling service. A total of 204 pregnancies resulted in 205 outcomes. Of the 100 sibships, 14 (14%) had more than 1 affected member. The pregnancy was shorter than 28 weeks in 56/205 (27%) of the total outcomes. Of 104 evaluable previous outcomes, 34 corresponded to short pregnancies, positioned before an affected (23/60, 38%), a healthy (2/18, 11%), or an undiagnosed product (9/26, 35%). Short pregnancies subsequent to affected outcomes were also increased. The inter-gestational interval varied according to diagnosis: it was longer in the affected group than in the healthy one (0.1 > p > 0.05) and the subsequent intervals were shorter for the affected group (p < 0.05). An increased number of abortions adjacent to affected offspring and a changing fertility pattern, depending on the product diagnosis, point to an environmental etiological component in this high- risk NTD group of mothers. Copyright (C) 2000 S. Karger AG, Basel.
KW - Neural tube defects
KW - Reproductive history
UR - http://www.scopus.com/inward/record.url?scp=0343619360&partnerID=8YFLogxK
U2 - 10.1159/000010255
DO - 10.1159/000010255
M3 - Article
C2 - 10828709
AN - SCOPUS:0343619360
SN - 0378-7346
VL - 49
SP - 255
EP - 260
JO - Gynecologic and Obstetric Investigation
JF - Gynecologic and Obstetric Investigation
IS - 4
ER -