Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia

James R. Hall; Leigh A. Johnson; Melissa Peterson; David Julovich; Tori Como; Sid E. O’bryant

doi:10.2174/1567205018666210219105949

Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia

James R. Hall, Leigh A. Johnson, Melissa Peterson, David Julovich, Tori Como, Sid E. O’bryant

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans. Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed. Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups. Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neu-rodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

Original language	English
Pages (from-to)	1214-1220
Number of pages	7
Journal	Current Alzheimer Research
Volume	17
Issue number	13
DOIs	https://doi.org/10.2174/1567205018666210219105949
State	Published - 2020

Keywords

Cognition processes
Dementia
MCI
Mexican americans
Neurofilament light
Normal cognition

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10.2174/1567205018666210219105949

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title = "Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia",

abstract = "Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans. Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed. Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups. Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neu-rodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.",

keywords = "Cognition processes, Dementia, MCI, Mexican americans, Neurofilament light, Normal cognition",

author = "Hall, {James R.} and Johnson, {Leigh A.} and Melissa Peterson and David Julovich and Tori Como and O{\textquoteright}bryant, {Sid E.}",

note = "Funding Information: Research was supported by the National Institute on Aging which is associated with the National Institutes of Health wAard Numbers 0R1AG039389 and P30AG12300. Funding Information: S.E.O. has received funding from the National Institute on Aging, Michael J. Fox Foundation, Alzheimer's Association; has multiple patents pending on precision medicine for neurodegenerative diseases; is the founding scientist for Cx Precision Medicine and has served as a consultant to Roche Diagnostics. J.R.H, L.A.J. M.P, T.C and D.J have nothing to disclose. Publisher Copyright: {\textcopyright} 2020 Bentham Science Publishers.",

year = "2020",

doi = "10.2174/1567205018666210219105949",

language = "English",

volume = "17",

pages = "1214--1220",

journal = "Current Alzheimer Research",

issn = "1567-2050",

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T1 - Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia

AU - Hall, James R.

AU - Johnson, Leigh A.

AU - Peterson, Melissa

AU - Julovich, David

AU - Como, Tori

AU - O’bryant, Sid E.

N1 - Funding Information: Research was supported by the National Institute on Aging which is associated with the National Institutes of Health wAard Numbers 0R1AG039389 and P30AG12300. Funding Information: S.E.O. has received funding from the National Institute on Aging, Michael J. Fox Foundation, Alzheimer's Association; has multiple patents pending on precision medicine for neurodegenerative diseases; is the founding scientist for Cx Precision Medicine and has served as a consultant to Roche Diagnostics. J.R.H, L.A.J. M.P, T.C and D.J have nothing to disclose. Publisher Copyright: © 2020 Bentham Science Publishers.

PY - 2020

Y1 - 2020

N2 - Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans. Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed. Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups. Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neu-rodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

AB - Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans. Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed. Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups. Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neu-rodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

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Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia

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