Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia

James R. Hall, Leigh A. Johnson, Melissa Peterson, David Julovich, Tori Como, Sid E. O’bryant

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans. Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed. Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups. Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neu-rodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.

Original languageEnglish
Pages (from-to)1214-1220
Number of pages7
JournalCurrent Alzheimer Research
Volume17
Issue number13
DOIs
StatePublished - 2020

Keywords

  • Cognition processes
  • Dementia
  • MCI
  • Mexican americans
  • Neurofilament light
  • Normal cognition

Fingerprint

Dive into the research topics of 'Relationship of neurofilament light (Nfl) and cognitive performance in a sample of mexican americans with normal cognition, mild cognitive impairment and dementia'. Together they form a unique fingerprint.

Cite this