Abstract
Introduction: This study characterized the relationship between plasma NfL and cognition in a community-based sample of older Mexican Americans. Methods: 544 participants completed a battery of neuropsychological tests and were diagnosed using clinical criteria. NfL was assayed using Simoa. NfL levels across groups and tests were analyzed. Results: Difference in NfL was found between normal and impaired groups and was related to global cognition, processing speed, executive functions and a list of learning tasks with a significant negative effect for all diagnostic groups. NfL had a negative impact on processing speed, attention, executive functions and delayed and recognition memory for both normal and MCI groups. Conclusion: The research supports plasma NfL as a marker of cognitive impairment related to neu-rodegenerative processes in Mexican Americans and may be a marker of early changes in cognition in those with normal cognition and at risk for developing MCI.
Original language | English |
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Pages (from-to) | 1214-1220 |
Number of pages | 7 |
Journal | Current Alzheimer Research |
Volume | 17 |
Issue number | 13 |
DOIs | |
State | Published - 2020 |
Keywords
- Cognition processes
- Dementia
- MCI
- Mexican americans
- Neurofilament light
- Normal cognition