TY - JOUR
T1 - Relationship between heterozygosity and genetic distance in the three major races of man
AU - Chakraborty, Ranajit
PY - 1984/11
Y1 - 1984/11
N2 - In pairwise comparisons of gene frequency data from the three major races of man, the single locus measures of the heterozygosity within and the genetic distance between races are shown to be strongly correlated across the loci coding for red cell proteins and enzymes. The intercept of the regression line of genetic distance on heterozygosity in protein enzyme loci is statistically insignificant. These findings suggest that the genetic variability at the enzyme and protein loci in man is probably maintained by a balance of mutation and random genetic drift. At the blood group loci, however, the observed relationship between genetic distance and heterozygosity does not follow the expectation of the neutral mutation hypothesis. These observations are discussed in terms of the changes in probability of identical monomorphism in two populations during the process of gene differentiation.
AB - In pairwise comparisons of gene frequency data from the three major races of man, the single locus measures of the heterozygosity within and the genetic distance between races are shown to be strongly correlated across the loci coding for red cell proteins and enzymes. The intercept of the regression line of genetic distance on heterozygosity in protein enzyme loci is statistically insignificant. These findings suggest that the genetic variability at the enzyme and protein loci in man is probably maintained by a balance of mutation and random genetic drift. At the blood group loci, however, the observed relationship between genetic distance and heterozygosity does not follow the expectation of the neutral mutation hypothesis. These observations are discussed in terms of the changes in probability of identical monomorphism in two populations during the process of gene differentiation.
KW - Genetic distance
KW - Heterozygosity
KW - Human racial variation
KW - Neutral mutation theory
UR - http://www.scopus.com/inward/record.url?scp=0021702994&partnerID=8YFLogxK
U2 - 10.1002/ajpa.1330650304
DO - 10.1002/ajpa.1330650304
M3 - Article
C2 - 6517153
AN - SCOPUS:0021702994
SN - 0002-9483
VL - 65
SP - 249
EP - 258
JO - American Journal of Physical Anthropology
JF - American Journal of Physical Anthropology
IS - 3
ER -