TY - JOUR
T1 - Regulation of fuel metabolism by preexercise muscle glycogen content and exercise intensity
AU - Arkinstall, Melissa J.
AU - Bruce, Clinton R.
AU - Clark, Sally A.
AU - Rickards, Caroline A.
AU - Burke, Louise M.
AU - Hawley, John A.
PY - 2004/12
Y1 - 2004/12
N2 - To date, the results of studies that have examined the effects of altering preexercise muscle glycogen content and exercise intensity on endogenous carbohydrate oxidation are equivocal. Differences in the training status of subjects between investigations may, in part, explain these inconsistent findings. Accordingly, we determined the relative effects of exercise intensity and carbohydrate availability on patterns of fuel utilization in the same subjects who performed a random order of four 60-min rides, two at 45% and two at 70% of peak O2 uptake (Vo2 peak), after exercise-diet intervention to manipulate muscle glycogen content. Preexercise muscle glycogen content was 596 ± 43 and 202 ± 21 mmol/kg dry mass (P < 0.001) for high-glycogen (HG) and low-glycogen (LG) conditions, respectively. Respiratory exchange ratio was higher for HG than LG during exercise at both 45% (0.85 ± 0.01 vs. 0.74 ± 0.01; P < 0.001) and 70% (0.90 ± 0.01 vs. 0.79 ± 0.01; P < 0.001) of Vo2 peak. The contribution of whole body muscle glycogen oxidation to energy expenditure differed between LG and HG for exercise at both 45% (5 ± 2 vs. 45 ± 5%; P < 0.001) and 70% (25 ± 3 vs. 60 ± 3%; P < 0.001) of Vo2peak. Yet, despite marked differences in preexercise muscle glycogen content and its subsequent utilization, rates of plasma glucose disappearance were similar under all conditions. We conclude that, in moderately trained individuals, muscle glycogen availability (low vs. high) does not influence rates of plasma glucose disposal during either low- or moderate-intensity exercise.
AB - To date, the results of studies that have examined the effects of altering preexercise muscle glycogen content and exercise intensity on endogenous carbohydrate oxidation are equivocal. Differences in the training status of subjects between investigations may, in part, explain these inconsistent findings. Accordingly, we determined the relative effects of exercise intensity and carbohydrate availability on patterns of fuel utilization in the same subjects who performed a random order of four 60-min rides, two at 45% and two at 70% of peak O2 uptake (Vo2 peak), after exercise-diet intervention to manipulate muscle glycogen content. Preexercise muscle glycogen content was 596 ± 43 and 202 ± 21 mmol/kg dry mass (P < 0.001) for high-glycogen (HG) and low-glycogen (LG) conditions, respectively. Respiratory exchange ratio was higher for HG than LG during exercise at both 45% (0.85 ± 0.01 vs. 0.74 ± 0.01; P < 0.001) and 70% (0.90 ± 0.01 vs. 0.79 ± 0.01; P < 0.001) of Vo2 peak. The contribution of whole body muscle glycogen oxidation to energy expenditure differed between LG and HG for exercise at both 45% (5 ± 2 vs. 45 ± 5%; P < 0.001) and 70% (25 ± 3 vs. 60 ± 3%; P < 0.001) of Vo2peak. Yet, despite marked differences in preexercise muscle glycogen content and its subsequent utilization, rates of plasma glucose disappearance were similar under all conditions. We conclude that, in moderately trained individuals, muscle glycogen availability (low vs. high) does not influence rates of plasma glucose disposal during either low- or moderate-intensity exercise.
KW - Diet
KW - Glucose rate of disappearance
KW - Training status
UR - http://www.scopus.com/inward/record.url?scp=9244239217&partnerID=8YFLogxK
U2 - 10.1152/japplphysiol.00421.2004
DO - 10.1152/japplphysiol.00421.2004
M3 - Article
C2 - 15286047
AN - SCOPUS:9244239217
SN - 8750-7587
VL - 97
SP - 2275
EP - 2283
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
IS - 6
ER -