TY - JOUR
T1 - Regulation of coronary blood flow
AU - Goodwill, Adam G.
AU - Dick, Gregory M.
AU - Kiel, Alexander M.
AU - Tune, Johnathan D.
N1 - Publisher Copyright:
© American Physiological Society.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through multiple mechanisms that include extravascular compressive forces (tissue pressure), coronary perfusion pressure, myogenic, local metabolic, endothelial as well as neural and hormonal influences. While each of these determinants can have profound influence over myocardial perfusion, largely through effects on end-effector ion channels, these mechanisms collectively modulate coronary vascular resistance and act to ensure that the myocardial requirements for oxygen and substrates are adequately provided by the coronary circulation. The purpose of this series of Comprehensive Physiology is to highlight current knowledge regarding the physiologic regulation of coronary blood flow, with emphasis on functional anatomy and the interplay between the physical and biological determinants of myocardial oxygen delivery.
AB - The heart is uniquely responsible for providing its own blood supply through the coronary circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of dedicated research, is understood to be dictated through multiple mechanisms that include extravascular compressive forces (tissue pressure), coronary perfusion pressure, myogenic, local metabolic, endothelial as well as neural and hormonal influences. While each of these determinants can have profound influence over myocardial perfusion, largely through effects on end-effector ion channels, these mechanisms collectively modulate coronary vascular resistance and act to ensure that the myocardial requirements for oxygen and substrates are adequately provided by the coronary circulation. The purpose of this series of Comprehensive Physiology is to highlight current knowledge regarding the physiologic regulation of coronary blood flow, with emphasis on functional anatomy and the interplay between the physical and biological determinants of myocardial oxygen delivery.
UR - http://www.scopus.com/inward/record.url?scp=85020996042&partnerID=8YFLogxK
U2 - 10.1002/cphy.c160016
DO - 10.1002/cphy.c160016
M3 - Article
C2 - 28333376
AN - SCOPUS:85020996042
SN - 2040-4603
VL - 7
SP - 321
EP - 382
JO - Comprehensive Physiology
JF - Comprehensive Physiology
IS - 2
ER -