Regulation of autophagy by kinases

Savitha Suffixidharan, Kirti Jain, Alakananda Basu

Research output: Contribution to journalReview articleResearchpeer-review

103 Citations (Scopus)

Abstract

Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated protein kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.

Original languageEnglish
Pages (from-to)2630-2654
Number of pages25
JournalCancers
Volume3
Issue number2
DOIs
StatePublished - 1 Jun 2011

Fingerprint

Autophagy
Phosphotransferases
Protein-Serine-Threonine Kinases
p38 Mitogen-Activated Protein Kinases
TOR Serine-Threonine Kinases
MAP Kinase Kinase 4
Physiological Stress
AMP-Activated Protein Kinases
Protein Kinases
Protein Kinase C
Neoplasms
Cell Death
Therapeutics

Keywords

  • AKT
  • AMPK
  • Autophagy
  • MAPK
  • MTOR
  • P70S6K
  • PI3K
  • PKC
  • Protein kinase

Cite this

Suffixidharan, Savitha ; Jain, Kirti ; Basu, Alakananda. / Regulation of autophagy by kinases. In: Cancers. 2011 ; Vol. 3, No. 2. pp. 2630-2654.
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title = "Regulation of autophagy by kinases",
abstract = "Autophagy is a process of self-degradation that maintains cellular viability during periods of metabolic stress. Although autophagy is considered a survival mechanism when faced with cellular stress, extensive autophagy can also lead to cell death. Aberrations in autophagy are associated with several diseases, including cancer. Therapeutic exploitation of this process requires a clear understanding of its regulation. Although the core molecular components involved in the execution of autophagy are well studied there is limited information on how cellular signaling pathways, particularly kinases, regulate this complex process. Protein kinases are integral to the autophagy process. Atg1, the first autophagy-related protein identified, is a serine/threonine kinase and it is regulated by another serine/threonine kinase mTOR. Emerging studies suggest the participation of many different kinases in regulating various components/steps of this catabolic process. This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated protein kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.",
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Suffixidharan, S, Jain, K & Basu, A 2011, 'Regulation of autophagy by kinases', Cancers, vol. 3, no. 2, pp. 2630-2654. https://doi.org/10.3390/cancers3022630

Regulation of autophagy by kinases. / Suffixidharan, Savitha; Jain, Kirti; Basu, Alakananda.

In: Cancers, Vol. 3, No. 2, 01.06.2011, p. 2630-2654.

Research output: Contribution to journalReview articleResearchpeer-review

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