Regional specific groundwater arsenic levels and neuropsychological functioning: A cross-sectional study

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7 Citations (Scopus)

Abstract

Background: The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. Methods: This cross-sectional study design analyzed data from 1390 participants (733 Alzheimers disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimers Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. Results: In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases. Conclusions: Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.

Original languageEnglish
Pages (from-to)546-557
Number of pages12
JournalInternational Journal of Environmental Health Research
Volume24
Issue number6
DOIs
StatePublished - 2 Nov 2014

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Groundwater
Arsenic
Cross-Sectional Studies
Short-Term Memory
Geographic information systems
Cognition
Data storage equipment
Geographic Information Systems
Aptitude
Telecommunication links
Alzheimer Disease
Language
Water
Research
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Groundwater
  • Mild cognitive impairment
  • Neuropsychology
  • arsenic

Cite this

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title = "Regional specific groundwater arsenic levels and neuropsychological functioning: A cross-sectional study",
abstract = "Background: The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. Methods: This cross-sectional study design analyzed data from 1390 participants (733 Alzheimers disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimers Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. Results: In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases. Conclusions: Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.",
keywords = "Alzheimer's disease, Groundwater, Mild cognitive impairment, Neuropsychology, arsenic",
author = "Melissa Edwards and Johnson, {Leigh A.} and Cortney Mauer and Barber, {Robert Clinton} and James Hall and Sidney O'Bryant",
year = "2014",
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doi = "10.1080/09603123.2014.883591",
language = "English",
volume = "24",
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journal = "International Journal of Environmental Health Research",
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TY - JOUR

T1 - Regional specific groundwater arsenic levels and neuropsychological functioning

T2 - A cross-sectional study

AU - Edwards, Melissa

AU - Johnson, Leigh A.

AU - Mauer, Cortney

AU - Barber, Robert Clinton

AU - Hall, James

AU - O'Bryant, Sidney

PY - 2014/11/2

Y1 - 2014/11/2

N2 - Background: The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. Methods: This cross-sectional study design analyzed data from 1390 participants (733 Alzheimers disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimers Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. Results: In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases. Conclusions: Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.

AB - Background: The purpose of the study was to examine the link between geographic information system (GIS)-estimated regional specific groundwater levels and neuropsychological functioning in a sample of individuals with and without cognitive impairment. Methods: This cross-sectional study design analyzed data from 1390 participants (733 Alzheimers disease, 127 Mild Cognitive Impairment, and 530 with normal cognition) enrolled in the Texas Alzheimers Research and Care Consortium. GISs analyses were used to estimate regional specific groundwater arsenic concentrations using the Environmental Systems Research Institute and arsenic concentrations from the Texas Water Development Board. Results: In the full cohort, regional specific arsenic concentrations were positively associated with language abilities (p = 0.008), but associated with poorer verbal memory, immediate (p = 0.008), and delayed (p < 0.001), as well as poorer visual memory, immediate (p = 0.02), and delayed (p < 0.001). The findings varied by diagnostic category with arsenic being related with cognition most prominently among mild cognitive impairment cases. Conclusions: Overall, estimated regional specific groundwater arsenic levels were negatively associated with neuropsychological performance.

KW - Alzheimer's disease

KW - Groundwater

KW - Mild cognitive impairment

KW - Neuropsychology

KW - arsenic

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