TY - JOUR
T1 - Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure
AU - Ma, Rong
AU - Zucker, Irving H.
AU - Wang, Wei
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1999/1
Y1 - 1999/1
N2 - The aim of the present study was to test the hypothesis that a decrease in central nitric oxide (NO) is involved in the enhancement of the central gain of the cardiac 'sympathetic afferent' reflex (CSAR) in dogs with congestive heart failure (CHF). Thirteen dogs with pacing-induced CHF and sixteen sham dogs were anesthetized with α-chloralose and were baroreceptor denervated and vagotomized. The CSAR was evoked by stimulation of the left ventral ansa. A lateral cerebroventricular cannula was inserted to deliver sodium nitroprusside (SNP) and N(G)-nitro-L-arginine methyl ester (L-NAME). Arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR. We found that 1) the responses of RSNA to stimulation were augmented in dogs with CHF, 2) SNP depressed the increase in RSNA induced by the CSAR in CHF dogs but had no effect in sham dogs, and 3) L-NAME potentiated the CSAR-induced increase in RSNA in sham dogs but not in dogs with CHF. We conclude that reduced central NO is involved in the enhanced central gain of the CSAR in CHF dogs.
AB - The aim of the present study was to test the hypothesis that a decrease in central nitric oxide (NO) is involved in the enhancement of the central gain of the cardiac 'sympathetic afferent' reflex (CSAR) in dogs with congestive heart failure (CHF). Thirteen dogs with pacing-induced CHF and sixteen sham dogs were anesthetized with α-chloralose and were baroreceptor denervated and vagotomized. The CSAR was evoked by stimulation of the left ventral ansa. A lateral cerebroventricular cannula was inserted to deliver sodium nitroprusside (SNP) and N(G)-nitro-L-arginine methyl ester (L-NAME). Arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR. We found that 1) the responses of RSNA to stimulation were augmented in dogs with CHF, 2) SNP depressed the increase in RSNA induced by the CSAR in CHF dogs but had no effect in sham dogs, and 3) L-NAME potentiated the CSAR-induced increase in RSNA in sham dogs but not in dogs with CHF. We conclude that reduced central NO is involved in the enhanced central gain of the CSAR in CHF dogs.
KW - Brain
KW - N(G)-nitro-L-arginine methyl ester
KW - Nitric oxide synthase
KW - Renal sympathetic nerve activity
KW - Sodium nitroprusside
UR - http://www.scopus.com/inward/record.url?scp=0032898481&partnerID=8YFLogxK
U2 - 10.1152/ajpheart.1999.276.1.h19
DO - 10.1152/ajpheart.1999.276.1.h19
M3 - Article
C2 - 9887012
AN - SCOPUS:0032898481
SN - 0363-6135
VL - 276
SP - H19-H26
JO - American Journal of Physiology - Heart and Circulatory Physiology
JF - American Journal of Physiology - Heart and Circulatory Physiology
IS - 1 45-1
ER -