Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure

Rong Ma, Irving H. Zucker, Wei Wang

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The aim of the present study was to test the hypothesis that a decrease in central nitric oxide (NO) is involved in the enhancement of the central gain of the cardiac 'sympathetic afferent' reflex (CSAR) in dogs with congestive heart failure (CHF). Thirteen dogs with pacing-induced CHF and sixteen sham dogs were anesthetized with α-chloralose and were baroreceptor denervated and vagotomized. The CSAR was evoked by stimulation of the left ventral ansa. A lateral cerebroventricular cannula was inserted to deliver sodium nitroprusside (SNP) and N(G)-nitro-L-arginine methyl ester (L-NAME). Arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR. We found that 1) the responses of RSNA to stimulation were augmented in dogs with CHF, 2) SNP depressed the increase in RSNA induced by the CSAR in CHF dogs but had no effect in sham dogs, and 3) L-NAME potentiated the CSAR-induced increase in RSNA in sham dogs but not in dogs with CHF. We conclude that reduced central NO is involved in the enhanced central gain of the CSAR in CHF dogs.

Original languageEnglish
Pages (from-to)H19-H26
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume276
Issue number1 45-1
StatePublished - 1 Jan 1999

Fingerprint

Reflex
Nitric Oxide
Heart Failure
Dogs
NG-Nitroarginine Methyl Ester
Kidney
Nitroprusside
Chloralose
Pressoreceptors
Arterial Pressure
Heart Rate

Keywords

  • Brain
  • N(G)-nitro-L-arginine methyl ester
  • Nitric oxide synthase
  • Renal sympathetic nerve activity
  • Sodium nitroprusside

Cite this

@article{15b6ace361594cfb8fa98a814aa6a4a8,
title = "Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure",
abstract = "The aim of the present study was to test the hypothesis that a decrease in central nitric oxide (NO) is involved in the enhancement of the central gain of the cardiac 'sympathetic afferent' reflex (CSAR) in dogs with congestive heart failure (CHF). Thirteen dogs with pacing-induced CHF and sixteen sham dogs were anesthetized with α-chloralose and were baroreceptor denervated and vagotomized. The CSAR was evoked by stimulation of the left ventral ansa. A lateral cerebroventricular cannula was inserted to deliver sodium nitroprusside (SNP) and N(G)-nitro-L-arginine methyl ester (L-NAME). Arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR. We found that 1) the responses of RSNA to stimulation were augmented in dogs with CHF, 2) SNP depressed the increase in RSNA induced by the CSAR in CHF dogs but had no effect in sham dogs, and 3) L-NAME potentiated the CSAR-induced increase in RSNA in sham dogs but not in dogs with CHF. We conclude that reduced central NO is involved in the enhanced central gain of the CSAR in CHF dogs.",
keywords = "Brain, N(G)-nitro-L-arginine methyl ester, Nitric oxide synthase, Renal sympathetic nerve activity, Sodium nitroprusside",
author = "Rong Ma and Zucker, {Irving H.} and Wei Wang",
year = "1999",
month = "1",
day = "1",
language = "English",
volume = "276",
pages = "H19--H26",
journal = "American Journal of Physiology - Heart and Circulatory Physiology",
issn = "0363-6135",
publisher = "American Physiological Society",
number = "1 45-1",

}

Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure. / Ma, Rong; Zucker, Irving H.; Wang, Wei.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 276, No. 1 45-1, 01.01.1999, p. H19-H26.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reduced NO enhances the central gain of cardiac sympathetic afferent reflex in dogs with heart failure

AU - Ma, Rong

AU - Zucker, Irving H.

AU - Wang, Wei

PY - 1999/1/1

Y1 - 1999/1/1

N2 - The aim of the present study was to test the hypothesis that a decrease in central nitric oxide (NO) is involved in the enhancement of the central gain of the cardiac 'sympathetic afferent' reflex (CSAR) in dogs with congestive heart failure (CHF). Thirteen dogs with pacing-induced CHF and sixteen sham dogs were anesthetized with α-chloralose and were baroreceptor denervated and vagotomized. The CSAR was evoked by stimulation of the left ventral ansa. A lateral cerebroventricular cannula was inserted to deliver sodium nitroprusside (SNP) and N(G)-nitro-L-arginine methyl ester (L-NAME). Arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR. We found that 1) the responses of RSNA to stimulation were augmented in dogs with CHF, 2) SNP depressed the increase in RSNA induced by the CSAR in CHF dogs but had no effect in sham dogs, and 3) L-NAME potentiated the CSAR-induced increase in RSNA in sham dogs but not in dogs with CHF. We conclude that reduced central NO is involved in the enhanced central gain of the CSAR in CHF dogs.

AB - The aim of the present study was to test the hypothesis that a decrease in central nitric oxide (NO) is involved in the enhancement of the central gain of the cardiac 'sympathetic afferent' reflex (CSAR) in dogs with congestive heart failure (CHF). Thirteen dogs with pacing-induced CHF and sixteen sham dogs were anesthetized with α-chloralose and were baroreceptor denervated and vagotomized. The CSAR was evoked by stimulation of the left ventral ansa. A lateral cerebroventricular cannula was inserted to deliver sodium nitroprusside (SNP) and N(G)-nitro-L-arginine methyl ester (L-NAME). Arterial pressure, heart rate, and renal sympathetic nerve activity (RSNA) were recorded at baseline and during elicitation of the CSAR. We found that 1) the responses of RSNA to stimulation were augmented in dogs with CHF, 2) SNP depressed the increase in RSNA induced by the CSAR in CHF dogs but had no effect in sham dogs, and 3) L-NAME potentiated the CSAR-induced increase in RSNA in sham dogs but not in dogs with CHF. We conclude that reduced central NO is involved in the enhanced central gain of the CSAR in CHF dogs.

KW - Brain

KW - N(G)-nitro-L-arginine methyl ester

KW - Nitric oxide synthase

KW - Renal sympathetic nerve activity

KW - Sodium nitroprusside

UR - http://www.scopus.com/inward/record.url?scp=0032898481&partnerID=8YFLogxK

M3 - Article

C2 - 9887012

AN - SCOPUS:0032898481

VL - 276

SP - H19-H26

JO - American Journal of Physiology - Heart and Circulatory Physiology

JF - American Journal of Physiology - Heart and Circulatory Physiology

SN - 0363-6135

IS - 1 45-1

ER -