Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly

Xiaoli Liu, Xiaoan Chen, Geoffrey Kline, Sarah E. Ross, James R. Hall, Yanfeng Ding, Robert T. Mallet, Xiangrong Shi

Research output: Contribution to journalArticle

Abstract

Background: The impact of aging on cerebrovascular function and tissue oxygenation during graded hypoxemia is incompletely known. This study compared the age effect on these variables during cyclic hypoxemia-reoxygenation. Methods: Hypoxia-induced changes in arterial (SaO2) and cerebral tissue (ScO2) O2 saturation, middle cerebral arterial flow velocity (VMCA), estimated cerebral vascular conductance (CVC), heart rate (HR) and ventilation were compared between 12 elderly (71 ± 2 yr, 7 women) and 13 young (24 ± 3 yr, 5 women) adults during the first and fifth 5-min exposures to 10% O2. Results: Although pre-hypoxia SaO2 did not differ between the groups, ScO2 was lower (P < 0.05) in the elderly (68.4 ± 1.2%) than young (73.8 ± 0.9%) adults, commensurate with a lower resting VMCA (P < 0.05). SaO2 fell less sharply (P < 0.05) in the elderly subjects during the first and fifth hypoxia exposures. Moreover, the responses of ScO2, VMCA, CVC, HR and breathing frequency to hypoxia were attenuated in the elderly subjects. Systolic and diastolic arterial pressures fell by 2–6 mmHg during hypoxia in both young and elderly. Thus, hypoxemia developed more gradually in elderly than young adults during normobaric hypoxia, concordant with a reduced metabolic demand in the elderly. Conclusions: The elderly adults safely tolerated cyclic, moderate hypoxemia which lowered SaO2 by 20–25%, despite dampening of cerebrovascular and cardiac responses to hypoxemia.

Original languageEnglish
Article number103306
JournalRespiratory Physiology and Neurobiology
Volume271
DOIs
StatePublished - Jan 2020

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Blood Vessels
Hypoxia
Heart Rate
Ventilation
Young Adult
Arterial Pressure
Respiration
Blood Pressure

Keywords

  • Aging
  • Arterial oxygen saturation
  • Cerebral blood flow
  • Cerebral tissue oxygenation
  • Heart rate
  • Hypoxemia
  • Ventilation

Cite this

@article{22e9b7841c05410287850d4ce51764ee,
title = "Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly",
abstract = "Background: The impact of aging on cerebrovascular function and tissue oxygenation during graded hypoxemia is incompletely known. This study compared the age effect on these variables during cyclic hypoxemia-reoxygenation. Methods: Hypoxia-induced changes in arterial (SaO2) and cerebral tissue (ScO2) O2 saturation, middle cerebral arterial flow velocity (VMCA), estimated cerebral vascular conductance (CVC), heart rate (HR) and ventilation were compared between 12 elderly (71 ± 2 yr, 7 women) and 13 young (24 ± 3 yr, 5 women) adults during the first and fifth 5-min exposures to 10{\%} O2. Results: Although pre-hypoxia SaO2 did not differ between the groups, ScO2 was lower (P < 0.05) in the elderly (68.4 ± 1.2{\%}) than young (73.8 ± 0.9{\%}) adults, commensurate with a lower resting VMCA (P < 0.05). SaO2 fell less sharply (P < 0.05) in the elderly subjects during the first and fifth hypoxia exposures. Moreover, the responses of ScO2, VMCA, CVC, HR and breathing frequency to hypoxia were attenuated in the elderly subjects. Systolic and diastolic arterial pressures fell by 2–6 mmHg during hypoxia in both young and elderly. Thus, hypoxemia developed more gradually in elderly than young adults during normobaric hypoxia, concordant with a reduced metabolic demand in the elderly. Conclusions: The elderly adults safely tolerated cyclic, moderate hypoxemia which lowered SaO2 by 20–25{\%}, despite dampening of cerebrovascular and cardiac responses to hypoxemia.",
keywords = "Aging, Arterial oxygen saturation, Cerebral blood flow, Cerebral tissue oxygenation, Heart rate, Hypoxemia, Ventilation",
author = "Xiaoli Liu and Xiaoan Chen and Geoffrey Kline and Ross, {Sarah E.} and Hall, {James R.} and Yanfeng Ding and Mallet, {Robert T.} and Xiangrong Shi",
year = "2020",
month = "1",
doi = "10.1016/j.resp.2019.103306",
language = "English",
volume = "271",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",

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Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly. / Liu, Xiaoli; Chen, Xiaoan; Kline, Geoffrey; Ross, Sarah E.; Hall, James R.; Ding, Yanfeng; Mallet, Robert T.; Shi, Xiangrong.

In: Respiratory Physiology and Neurobiology, Vol. 271, 103306, 01.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Reduced cerebrovascular and cardioventilatory responses to intermittent hypoxia in elderly

AU - Liu, Xiaoli

AU - Chen, Xiaoan

AU - Kline, Geoffrey

AU - Ross, Sarah E.

AU - Hall, James R.

AU - Ding, Yanfeng

AU - Mallet, Robert T.

AU - Shi, Xiangrong

PY - 2020/1

Y1 - 2020/1

N2 - Background: The impact of aging on cerebrovascular function and tissue oxygenation during graded hypoxemia is incompletely known. This study compared the age effect on these variables during cyclic hypoxemia-reoxygenation. Methods: Hypoxia-induced changes in arterial (SaO2) and cerebral tissue (ScO2) O2 saturation, middle cerebral arterial flow velocity (VMCA), estimated cerebral vascular conductance (CVC), heart rate (HR) and ventilation were compared between 12 elderly (71 ± 2 yr, 7 women) and 13 young (24 ± 3 yr, 5 women) adults during the first and fifth 5-min exposures to 10% O2. Results: Although pre-hypoxia SaO2 did not differ between the groups, ScO2 was lower (P < 0.05) in the elderly (68.4 ± 1.2%) than young (73.8 ± 0.9%) adults, commensurate with a lower resting VMCA (P < 0.05). SaO2 fell less sharply (P < 0.05) in the elderly subjects during the first and fifth hypoxia exposures. Moreover, the responses of ScO2, VMCA, CVC, HR and breathing frequency to hypoxia were attenuated in the elderly subjects. Systolic and diastolic arterial pressures fell by 2–6 mmHg during hypoxia in both young and elderly. Thus, hypoxemia developed more gradually in elderly than young adults during normobaric hypoxia, concordant with a reduced metabolic demand in the elderly. Conclusions: The elderly adults safely tolerated cyclic, moderate hypoxemia which lowered SaO2 by 20–25%, despite dampening of cerebrovascular and cardiac responses to hypoxemia.

AB - Background: The impact of aging on cerebrovascular function and tissue oxygenation during graded hypoxemia is incompletely known. This study compared the age effect on these variables during cyclic hypoxemia-reoxygenation. Methods: Hypoxia-induced changes in arterial (SaO2) and cerebral tissue (ScO2) O2 saturation, middle cerebral arterial flow velocity (VMCA), estimated cerebral vascular conductance (CVC), heart rate (HR) and ventilation were compared between 12 elderly (71 ± 2 yr, 7 women) and 13 young (24 ± 3 yr, 5 women) adults during the first and fifth 5-min exposures to 10% O2. Results: Although pre-hypoxia SaO2 did not differ between the groups, ScO2 was lower (P < 0.05) in the elderly (68.4 ± 1.2%) than young (73.8 ± 0.9%) adults, commensurate with a lower resting VMCA (P < 0.05). SaO2 fell less sharply (P < 0.05) in the elderly subjects during the first and fifth hypoxia exposures. Moreover, the responses of ScO2, VMCA, CVC, HR and breathing frequency to hypoxia were attenuated in the elderly subjects. Systolic and diastolic arterial pressures fell by 2–6 mmHg during hypoxia in both young and elderly. Thus, hypoxemia developed more gradually in elderly than young adults during normobaric hypoxia, concordant with a reduced metabolic demand in the elderly. Conclusions: The elderly adults safely tolerated cyclic, moderate hypoxemia which lowered SaO2 by 20–25%, despite dampening of cerebrovascular and cardiac responses to hypoxemia.

KW - Aging

KW - Arterial oxygen saturation

KW - Cerebral blood flow

KW - Cerebral tissue oxygenation

KW - Heart rate

KW - Hypoxemia

KW - Ventilation

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U2 - 10.1016/j.resp.2019.103306

DO - 10.1016/j.resp.2019.103306

M3 - Article

C2 - 31557538

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VL - 271

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

M1 - 103306

ER -