Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthase

Keyphrases

• Reconstitution 100%
• FK228 100%
• Fatty Acid Synthase 100%
• Biosynthetic Pathway 100%
• Modular Polyketide Synthase 100%
• Acyltransferase 57%
• Polyketide Synthase 28%
• Anticancer 14%
• Microorganisms 14%
• Nonribosomal Peptide Synthetase 14%
• Secondary Metabolism 14%
• Natural Product Biosynthesis 14%
• Chromobacterium Violaceum 14%
• Gene Cluster 14%
• Gene Products 14%
• Depsipeptide 14%
• Genetic Components 14%
• Chain Elongation 14%
• Encoding Gene 14%
• Tumor Targeting 14%
• Cultivation Conditions 14%
• Bacterial Strains 14%
• Significant Level 14%
• Housekeeping 14%
• Trans-complementation 14%
• Aerobic Cultivation 14%
• Escherichia Coli Cells 14%
• Polyketides 14%
• Biosynthetic Enzymes 14%
• Fatty Acid Biosynthesis 14%
• Malonyl 14%
• Engineered E. Coli 14%
• Coenzyme A 14%
• Anaerobic Cultivation 14%
• Bioagents 14%
• Polyketide Synthase Pathway 14%
• Anaerobic Production 14%

Biochemistry, Genetics and Molecular Biology

• Anabolism 100%
• Polyketide Synthase 100%
• Fatty Acid Synthase 100%
• Romidepsin 100%
• Acyltransferase 57%
• N-Acetyltransferase 57%
• Escherichia coli 28%
• Enzyme 28%
• Genetics 14%
• Microorganism 14%
• Nonribosomal Peptide 14%
• Gene Cluster 14%
• Secondary Metabolism 14%
• Chromobacterium violaceum 14%
• Anticancer 14%
• Depsipeptide 14%
• Gene Product 14%
• Fatty Acid Synthesis 14%
• Malonyl-CoA 14%
• Essential Gene 14%
• Polyketide 14%
• Bacterial Strain 14%

Immunology and Microbiology

• Escherichia coli 100%
• Biosynthesis 100%
• Secondary Metabolism 50%
• Gene Cluster 50%
• Gene Product 50%
• Chromobacterium violaceum 50%
• Essential Gene 50%
• Bacterial Strain 50%
• Fatty Acid Synthesis 50%
• Microorganism 50%
• Coenzyme 50%