Recognition of a special membrane antigen of squamous cell carcinoma in rats with a monoclonal antibody ub23

Xinwei Li; Yoshihisa Fujikura; Yu Hsueh Wang; Tomoo Sawada; Nobuko Tokuda; Rehana Sultana Lovely; Yoshikazu Hayatsu; Tetsuo Fukumoto; Fumihiko Shinozaki

doi:10.1159/000218049

Recognition of a special membrane antigen of squamous cell carcinoma in rats with a monoclonal antibody ub23

Xinwei Li, Yoshihisa Fujikura, Yu Hsueh Wang, Tomoo Sawada, Nobuko Tokuda, Rehana Sultana Lovely, Yoshikazu Hayatsu, Tetsuo Fukumoto, Fumihiko Shinozaki

Research output: Contribution to journal › Article › peer-review

Abstract

This article describes the recognition of a special membrane antigen of the rat squamous cell carcinoma (SCC) by a monoclonal antibody (mAb), UB23, and the characterization of the UB23 antigen expression in the implanted primary and metastatic SCC in rat models. The mAb UB23 was raised against the FF6 tumor, a well-differentiated rat SCC, and it recognized the 120- to 130-kD cell surface antigen in FF6 tumor cells. The UB23 antigen was found in frequently observed small ‘basal’ cells but not in keratinocytes, and an increased expression was seen in the cells at the interface with peritumoral stroma in both the implanted primary FF6 tumors and metastases. These results indicated that the UB23 antigen is closely related with the cell differentiation and invasion of FF6 cells, and could be useful for analyzing the mechanism of differentiation, invasion and metastasis of SCC in animal models.

Original language	English
Pages (from-to)	350-355
Number of pages	6
Journal	Tumor Biology
Volume	18
Issue number	6
DOIs	https://doi.org/10.1159/000218049
State	Published - 1 Jan 1997

Keywords

FF6
Metastasis
Squamous cell carcinoma
UB23

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10.1159/000218049

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title = "Recognition of a special membrane antigen of squamous cell carcinoma in rats with a monoclonal antibody ub23",

abstract = "This article describes the recognition of a special membrane antigen of the rat squamous cell carcinoma (SCC) by a monoclonal antibody (mAb), UB23, and the characterization of the UB23 antigen expression in the implanted primary and metastatic SCC in rat models. The mAb UB23 was raised against the FF6 tumor, a well-differentiated rat SCC, and it recognized the 120- to 130-kD cell surface antigen in FF6 tumor cells. The UB23 antigen was found in frequently observed small {\textquoteleft}basal{\textquoteright} cells but not in keratinocytes, and an increased expression was seen in the cells at the interface with peritumoral stroma in both the implanted primary FF6 tumors and metastases. These results indicated that the UB23 antigen is closely related with the cell differentiation and invasion of FF6 cells, and could be useful for analyzing the mechanism of differentiation, invasion and metastasis of SCC in animal models.",

keywords = "FF6, Metastasis, Squamous cell carcinoma, UB23",

author = "Xinwei Li and Yoshihisa Fujikura and Wang, {Yu Hsueh} and Tomoo Sawada and Nobuko Tokuda and Lovely, {Rehana Sultana} and Yoshikazu Hayatsu and Tetsuo Fukumoto and Fumihiko Shinozaki",

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doi = "10.1159/000218049",

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AU - Li, Xinwei

AU - Fujikura, Yoshihisa

AU - Wang, Yu Hsueh

AU - Sawada, Tomoo

AU - Tokuda, Nobuko

AU - Lovely, Rehana Sultana

AU - Hayatsu, Yoshikazu

AU - Fukumoto, Tetsuo

AU - Shinozaki, Fumihiko

PY - 1997/1/1

Y1 - 1997/1/1

N2 - This article describes the recognition of a special membrane antigen of the rat squamous cell carcinoma (SCC) by a monoclonal antibody (mAb), UB23, and the characterization of the UB23 antigen expression in the implanted primary and metastatic SCC in rat models. The mAb UB23 was raised against the FF6 tumor, a well-differentiated rat SCC, and it recognized the 120- to 130-kD cell surface antigen in FF6 tumor cells. The UB23 antigen was found in frequently observed small ‘basal’ cells but not in keratinocytes, and an increased expression was seen in the cells at the interface with peritumoral stroma in both the implanted primary FF6 tumors and metastases. These results indicated that the UB23 antigen is closely related with the cell differentiation and invasion of FF6 cells, and could be useful for analyzing the mechanism of differentiation, invasion and metastasis of SCC in animal models.

AB - This article describes the recognition of a special membrane antigen of the rat squamous cell carcinoma (SCC) by a monoclonal antibody (mAb), UB23, and the characterization of the UB23 antigen expression in the implanted primary and metastatic SCC in rat models. The mAb UB23 was raised against the FF6 tumor, a well-differentiated rat SCC, and it recognized the 120- to 130-kD cell surface antigen in FF6 tumor cells. The UB23 antigen was found in frequently observed small ‘basal’ cells but not in keratinocytes, and an increased expression was seen in the cells at the interface with peritumoral stroma in both the implanted primary FF6 tumors and metastases. These results indicated that the UB23 antigen is closely related with the cell differentiation and invasion of FF6 cells, and could be useful for analyzing the mechanism of differentiation, invasion and metastasis of SCC in animal models.

KW - FF6

KW - Metastasis

KW - Squamous cell carcinoma

KW - UB23

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SP - 350

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JO - Tumor Biology

JF - Tumor Biology

IS - 6

ER -

Recognition of a special membrane antigen of squamous cell carcinoma in rats with a monoclonal antibody ub23

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Keywords

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