Recent progress in vascular aging: Mechanisms and its role in age-related diseases

Xianglai Xu, Brian Wang, Changhong Ren, Jiangnan Hu, David A. Greenberg, Tianxiang Chen, Liping Xie, Kunlin Jin

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFβ-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.

Original languageEnglish
Article number0507
JournalAging and Disease
Volume8
Issue number4
DOIs
StatePublished - 1 Jan 2017

Fingerprint

Blood Vessels
Vascular Dementia
Calpain
Chemokine CCL2
Metalloproteases
Renin-Angiotensin System
Vascular Diseases
Testosterone
Estrogens
Stroke
Therapeutics

Keywords

  • Arterial stiffness
  • Dementia
  • Endothelial dysfunction
  • Stroke
  • Vascular aging

Cite this

Xu, Xianglai ; Wang, Brian ; Ren, Changhong ; Hu, Jiangnan ; Greenberg, David A. ; Chen, Tianxiang ; Xie, Liping ; Jin, Kunlin. / Recent progress in vascular aging : Mechanisms and its role in age-related diseases. In: Aging and Disease. 2017 ; Vol. 8, No. 4.
@article{2d4ba6e99ad9425e92e17ea756c54fae,
title = "Recent progress in vascular aging: Mechanisms and its role in age-related diseases",
abstract = "As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFβ-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.",
keywords = "Arterial stiffness, Dementia, Endothelial dysfunction, Stroke, Vascular aging",
author = "Xianglai Xu and Brian Wang and Changhong Ren and Jiangnan Hu and Greenberg, {David A.} and Tianxiang Chen and Liping Xie and Kunlin Jin",
year = "2017",
month = "1",
day = "1",
doi = "10.14336/AD.2017.0507",
language = "English",
volume = "8",
journal = "Aging and Disease",
issn = "2152-5250",
publisher = "International Society on Aging and Disease",
number = "4",

}

Recent progress in vascular aging : Mechanisms and its role in age-related diseases. / Xu, Xianglai; Wang, Brian; Ren, Changhong; Hu, Jiangnan; Greenberg, David A.; Chen, Tianxiang; Xie, Liping; Jin, Kunlin.

In: Aging and Disease, Vol. 8, No. 4, 0507, 01.01.2017.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Recent progress in vascular aging

T2 - Mechanisms and its role in age-related diseases

AU - Xu, Xianglai

AU - Wang, Brian

AU - Ren, Changhong

AU - Hu, Jiangnan

AU - Greenberg, David A.

AU - Chen, Tianxiang

AU - Xie, Liping

AU - Jin, Kunlin

PY - 2017/1/1

Y1 - 2017/1/1

N2 - As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFβ-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.

AB - As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFβ-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.

KW - Arterial stiffness

KW - Dementia

KW - Endothelial dysfunction

KW - Stroke

KW - Vascular aging

UR - http://www.scopus.com/inward/record.url?scp=85032290788&partnerID=8YFLogxK

U2 - 10.14336/AD.2017.0507

DO - 10.14336/AD.2017.0507

M3 - Review article

AN - SCOPUS:85032290788

VL - 8

JO - Aging and Disease

JF - Aging and Disease

SN - 2152-5250

IS - 4

M1 - 0507

ER -