Recent progress in vascular aging: Mechanisms and its role in age-related diseases

Xianglai Xu, Brian Wang, Changhong Ren, Jiangnan Hu, David A. Greenberg, Tianxiang Chen, Liping Xie, Kunlin Jin

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


As with many age-related diseases including vascular dysfunction, age is considered an independent and crucial risk factor. Complicated alterations of structure and function in the vasculature are linked with aging hence, understanding the underlying mechanisms of age-induced vascular pathophysiological changes holds possibilities for developing clinical diagnostic methods and new therapeutic strategies. Here, we discuss the underlying molecular mediators that could be involved in vascular aging, e.g., the renin-angiotensin system and pro-inflammatory factors, metalloproteinases, calpain-1, monocyte chemoattractant protein-1 (MCP-1) and TGFβ-1 as well as the potential roles of testosterone and estrogen. We then relate all of these to clinical manifestations such as vascular dementia and stroke in addition to reviewing the existing clinical measurements and potential interventions for age-related vascular dysfunction.

Original languageEnglish
Article number0507
JournalAging and Disease
Issue number4
StatePublished - 2017


  • Arterial stiffness
  • Dementia
  • Endothelial dysfunction
  • Stroke
  • Vascular aging

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