Rationale and Design of the Randomized Controlled Trial of New Oral Anticoagulants Versus Warfarin for Post Cardiac Surgery Atrial Fibrillation: The NEW-AF Trial

Asishana A. Osho, Philicia Moonsamy, Breanna R. Ethridge, Gregory A. Leya, David A. D'alessandro, Arminder S. Jassar, Mauricio A. Villavicencio, Serguei I. Melnitchouk, George Tolis, Nathaniel B. Langer, Masaki Funamoto, Selena S. Li, Katia M. Colon, Navyatha Mohan, Joseph J. Locascio, Steven A. Lubitz, Oluwaseun Akeju, Thoralf M. Sundt

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Objective:This manuscript describes the rationale and design of a randomized, controlled trial comparing outcomes with Warfarin vs Novel Oral Anticoagulant (NOAC) therapy in patients with new onset atrial fibrillation after cardiac surgery.Background:New onset atrial fibrillation commonly occurs after cardiac surgery and is associated with increased rates of stroke and mortality. in nonsurgical patients with atrial fibrillation, NOACs have been shown to confer equivalent benefits for stroke prevention with less bleeding risk and less tedious monitoring requirements compared with Warfarin. However, NOAC use has yet to be adopted widely in cardiac surgery patients.Methods:The NEW-AF study has been designed as a pragmatic, prospective, randomized controlled trial that will compare financial, convenience and safety outcomes for patients with new onset atrial fibrillation after cardiac surgery that are treated with NOACs versus WarfarinResults:Study results may contribute to optimizing the options for stroke prophylaxis in cardiac surgery patients and catalyze more widespread application of NOAC therapy in this patient population.Conclusions:The study is ongoing and actively enrolling at the time of the publication. The trial is registered with clinicaltrials.gov under registration number NCT03702582.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalAnnals of Surgery
Volume276
Issue number1
DOIs
StatePublished - 1 Jul 2022

Keywords

  • atrial fibrillation
  • cardiac surgery
  • novel oral anticoagulant (NOAC)
  • trial design
  • warfarin

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