Rat supraoptic neurons are resistant to glutamate neurotoxicity

Bin Hu; J. Thomas Cunningham; Ralph Nissen; Leo P. Renaud; Charles W. Bourque

doi:10.1097/00001756-199201000-00023

Rat supraoptic neurons are resistant to glutamate neurotoxicity

Bin Hu, J. Thomas Cunningham, Ralph Nissen, Leo P. Renaud, Charles W. Bourque

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15 Scopus citations

Abstract

Magnocellular neurosecretory cells of the supraoptic nucleus (SON) are thought to be endogenously resistant to glutamate toxicity. In this study, we sought physiological and morphological evidence of this resistance in rats that received multiple peri-nuclear injections of ibotenate. In this preparation, ibotenate produced a large necrotic zone encompassing the SON but not within the nucleus itself. Extracellular recordings in vivo from 68 'spared' SON neurons from lesioned rats revealed normal patterns of electrical activity. Intracellular analysis in vitro from 13 'spared' SON neurons indicated that their intrinsic membrane properties, osmosensitivity and spontaneous synaptic activity did not differ significantly from that of controls. We conclude that SON neurons retain both a morphological and a physiological resistance to glutamate neurotoxicity.

Original language	English
Pages (from-to)	87-90
Number of pages	4
Journal	NeuroReport
Volume	3
Issue number	1
DOIs	https://doi.org/10.1097/00001756-199201000-00023
State	Published - Jan 1992

Keywords

Glutamate neurotoxicity
Hypothalamic supraoptic neurons
Osmosensitivity
Survival

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10.1097/00001756-199201000-00023

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title = "Rat supraoptic neurons are resistant to glutamate neurotoxicity",

abstract = "Magnocellular neurosecretory cells of the supraoptic nucleus (SON) are thought to be endogenously resistant to glutamate toxicity. In this study, we sought physiological and morphological evidence of this resistance in rats that received multiple peri-nuclear injections of ibotenate. In this preparation, ibotenate produced a large necrotic zone encompassing the SON but not within the nucleus itself. Extracellular recordings in vivo from 68 'spared' SON neurons from lesioned rats revealed normal patterns of electrical activity. Intracellular analysis in vitro from 13 'spared' SON neurons indicated that their intrinsic membrane properties, osmosensitivity and spontaneous synaptic activity did not differ significantly from that of controls. We conclude that SON neurons retain both a morphological and a physiological resistance to glutamate neurotoxicity.",

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T1 - Rat supraoptic neurons are resistant to glutamate neurotoxicity

AU - Hu, Bin

AU - Cunningham, J. Thomas

AU - Nissen, Ralph

AU - Renaud, Leo P.

AU - Bourque, Charles W.

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N2 - Magnocellular neurosecretory cells of the supraoptic nucleus (SON) are thought to be endogenously resistant to glutamate toxicity. In this study, we sought physiological and morphological evidence of this resistance in rats that received multiple peri-nuclear injections of ibotenate. In this preparation, ibotenate produced a large necrotic zone encompassing the SON but not within the nucleus itself. Extracellular recordings in vivo from 68 'spared' SON neurons from lesioned rats revealed normal patterns of electrical activity. Intracellular analysis in vitro from 13 'spared' SON neurons indicated that their intrinsic membrane properties, osmosensitivity and spontaneous synaptic activity did not differ significantly from that of controls. We conclude that SON neurons retain both a morphological and a physiological resistance to glutamate neurotoxicity.

AB - Magnocellular neurosecretory cells of the supraoptic nucleus (SON) are thought to be endogenously resistant to glutamate toxicity. In this study, we sought physiological and morphological evidence of this resistance in rats that received multiple peri-nuclear injections of ibotenate. In this preparation, ibotenate produced a large necrotic zone encompassing the SON but not within the nucleus itself. Extracellular recordings in vivo from 68 'spared' SON neurons from lesioned rats revealed normal patterns of electrical activity. Intracellular analysis in vitro from 13 'spared' SON neurons indicated that their intrinsic membrane properties, osmosensitivity and spontaneous synaptic activity did not differ significantly from that of controls. We conclude that SON neurons retain both a morphological and a physiological resistance to glutamate neurotoxicity.

KW - Glutamate neurotoxicity

KW - Hypothalamic supraoptic neurons

KW - Osmosensitivity

KW - Survival

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Rat supraoptic neurons are resistant to glutamate neurotoxicity

Abstract

Keywords

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