Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Keyphrases

• Alzheimer's Disease 100%
• Innate Immunity 100%
• Microglia 100%
• Minor Allele Frequency 100%
• Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) 100%
• PLCG2 100%
• Rare Coding Variants 100%
• ABI3 100%
• Odds Ratio 50%
• Frequency Control 50%
• Imputed Genotypes 33%
• Microarray 16%
• Innate Immune Response 16%
• Susceptibility Genes 16%
• Genetic Findings 16%
• Whole Exome 16%
• Protective Variants 16%
• Protein-protein Interaction Network 16%
• Risk Genes 16%
• Immune-related Proteins 16%
• Synonymous Variant 16%
• Risk Variant 16%

Biochemistry, Genetics and Molecular Biology

• Innate Immunity 100%
• TREM2 100%
• Minor Allele Frequency 100%
• Microglia 33%
• Genotyping 16%
• Genetics 16%
• Protein-Protein Interaction 16%
• Microarrays 16%
• Case-Control Study 16%
• Exome 16%

Neuroscience

• Alzheimer's Disease 100%
• Allele Frequency 100%
• Microglia 33%
• Protein-Protein Interaction 16%
• Microarrays 16%