Pyruvate enhancement of cardiac performance: Cellular mechanisms and clinical application

Keyphrases

• Cellular Mechanisms 100%
• Clinical Application 100%
• Cardiac Performance 100%
• Cardiopulmonary Bypass 100%
• Adenosine Triphosphate 80%
• Free Energy 80%
• Hydrolysis 60%
• Inflammation 60%
• Isolated Heart 60%
• Antioxidant System 40%
• Intracoronary 40%
• Ischemia-reperfusion Injury 40%
• Hypovolemia 40%
• Complex Injury 40%
• Glutathione Redox State 40%
• Cardioprotection 40%
• Cardioplegia 40%
• Adrenergic Signaling 40%
• Preclinical Research 40%
• Ischemia 20%
• Reperfusion 20%
• Stunned Myocardium 20%
• Antioxidant 20%
• Nicotinamide Adenine Dinucleotide Phosphate (NADPH) 20%
• Clinical Trials 20%
• Oxidative Stress 20%
• Cardiovascular Disease 20%
• Ca2+ 20%
• Functional Impact 20%
• Clinical Outcomes 20%
• Mechanical Performance 20%
• Heart Failure 20%
• Plasma Concentration 20%
• Septic Shock 20%
• Energy Substrates 20%
• Antioxidant Effect 20%
• Clinical Intervention 20%
• Supraphysiological 20%
• Intermediary Metabolites 20%
• Receiver Operating Characteristic Analysis 20%
• Ca2+ Release 20%
• Metabolic Effects 20%
• Ischemic Myocardium 20%
• Favorable Outcome 20%
• Canine Model 20%
• Pyruvate Therapy 20%
• Reactive Oxygen Intermediates 20%
• Intracellular Ca2+ Homeostasis 20%
• Support Recovery 20%
• Porcine Model 20%
• Intracoronary Infusion 20%
• High Demand 20%
• Congestive Heart Failure 20%
• Anti-inflammatory Agents 20%
• Phase One Trial 20%
• Fluid Resuscitation 20%
• Resuscitation 20%
• Curb 20%
• Large Mammals 20%
• Lactate Acid 20%
• Reuptake 20%
• Blood Supply 20%
• Fatty Acids 20%
• Caprine Model 20%
• Metabolic Support 20%
• Mismanagement 20%
• Metabolic Fuels 20%
• Metabolic Substrates 20%
• Reduced Form 20%
• Cardiac Contractility 20%
• Reactive Nitrogen Intermediates 20%
• Reticle 20%
• Lactate 20%
• Myocardium at Risk 20%
• Myocardium 20%
• Myocardial Contraction 20%
• Hindlimb 20%

Medicine and Dentistry

• Pyruvic Acid 100%
• Cellular Mechanism 100%
• Heart Performance 100%
• Cardiopulmonary Bypass 45%
• Antioxidant 36%
• Adenosine Triphosphate 36%
• Pyruvic Acid Derivative 36%
• Myocardium 27%
• Calcium Ion 27%
• Enzymatic Hydrolysis 27%
• Injury 18%
• Glutathione 18%
• Contractile Function 18%
• Lactic Acid 18%
• Cardioplegia 18%
• Hypovolemia 18%
• Congestive Heart Failure 18%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate 9%
• Ischemia 9%
• Reactive Oxygen Species 9%
• Oxidative Stress 9%
• Cardiovascular Disease 9%
• Vascularity 9%
• Clinical Trial 9%
• Septic Shock 9%
• Fluid Resuscitation 9%
• Antiinflammatory Agent 9%
• Hindlimb 9%
• Heart Muscle Ischemia 9%
• Resuscitation 9%
• Metabolite 9%
• Clinical Intervention 9%
• Fatty Acid 9%
• Isolated Heart 9%
• Intracoronary Drug Administration 9%
• Homeostasis 9%