Pulmonary impairment after tuberculosis and its contribution to TB burden

Jotam G. Pasipanodya, Scott Jn McNabb, Peter Hilsenrath, Sejong Bae, Kristine Lykens, Edgar Vecino, Guadalupe Munguia, Thaddeus L. Miller, Gerry Drewyer, Stephen Weis

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Abstract

Background. The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs). Methods. TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis. Results. There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23% were from years of life-lost, 2% were from years lived-with-disability-acute and 75% were from years lived-with-disability- chronic. Conclusions. Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.

Original languageEnglish
Article number259
JournalBMC Public Health
Volume10
DOIs
StatePublished - 21 May 2010

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Tuberculosis
Lung
Quality-Adjusted Life Years
Life Tables
Health
Cost of Illness
Life Expectancy
Pulmonary Tuberculosis
Therapeutics
Public Health

Cite this

Pasipanodya, J. G., McNabb, S. J., Hilsenrath, P., Bae, S., Lykens, K., Vecino, E., ... Weis, S. (2010). Pulmonary impairment after tuberculosis and its contribution to TB burden. BMC Public Health, 10, [259]. https://doi.org/10.1186/1471-2458-10-259
Pasipanodya, Jotam G. ; McNabb, Scott Jn ; Hilsenrath, Peter ; Bae, Sejong ; Lykens, Kristine ; Vecino, Edgar ; Munguia, Guadalupe ; Miller, Thaddeus L. ; Drewyer, Gerry ; Weis, Stephen. / Pulmonary impairment after tuberculosis and its contribution to TB burden. In: BMC Public Health. 2010 ; Vol. 10.
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title = "Pulmonary impairment after tuberculosis and its contribution to TB burden",
abstract = "Background. The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs). Methods. TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis. Results. There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23{\%} were from years of life-lost, 2{\%} were from years lived-with-disability-acute and 75{\%} were from years lived-with-disability- chronic. Conclusions. Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.",
author = "Pasipanodya, {Jotam G.} and McNabb, {Scott Jn} and Peter Hilsenrath and Sejong Bae and Kristine Lykens and Edgar Vecino and Guadalupe Munguia and Miller, {Thaddeus L.} and Gerry Drewyer and Stephen Weis",
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Pasipanodya, JG, McNabb, SJ, Hilsenrath, P, Bae, S, Lykens, K, Vecino, E, Munguia, G, Miller, TL, Drewyer, G & Weis, S 2010, 'Pulmonary impairment after tuberculosis and its contribution to TB burden', BMC Public Health, vol. 10, 259. https://doi.org/10.1186/1471-2458-10-259

Pulmonary impairment after tuberculosis and its contribution to TB burden. / Pasipanodya, Jotam G.; McNabb, Scott Jn; Hilsenrath, Peter; Bae, Sejong; Lykens, Kristine; Vecino, Edgar; Munguia, Guadalupe; Miller, Thaddeus L.; Drewyer, Gerry; Weis, Stephen.

In: BMC Public Health, Vol. 10, 259, 21.05.2010.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Pasipanodya, Jotam G.

AU - McNabb, Scott Jn

AU - Hilsenrath, Peter

AU - Bae, Sejong

AU - Lykens, Kristine

AU - Vecino, Edgar

AU - Munguia, Guadalupe

AU - Miller, Thaddeus L.

AU - Drewyer, Gerry

AU - Weis, Stephen

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N2 - Background. The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs). Methods. TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis. Results. There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23% were from years of life-lost, 2% were from years lived-with-disability-acute and 75% were from years lived-with-disability- chronic. Conclusions. Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.

AB - Background. The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs). Methods. TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis. Results. There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23% were from years of life-lost, 2% were from years lived-with-disability-acute and 75% were from years lived-with-disability- chronic. Conclusions. Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.

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Pasipanodya JG, McNabb SJ, Hilsenrath P, Bae S, Lykens K, Vecino E et al. Pulmonary impairment after tuberculosis and its contribution to TB burden. BMC Public Health. 2010 May 21;10. 259. https://doi.org/10.1186/1471-2458-10-259