@article{281b83ddad954603add44946a752ceec,
title = "Proteomic profiles of prevalent mild cognitive impairment and Alzheimer's disease among adults with Down syndrome",
abstract = "Introduction: We sought to determine if a proteomic profile approach developed to detect Alzheimer's disease (AD) in the general population would apply to adults with Down syndrome (DS). Methods: Plasma samples were obtained from 398 members of a community-based cohort of adults with DS. A total of n = 186 participants were determined to be non-demented and without mild cognitive impairment (MCI) at baseline and throughout follow-up; n = 50 had prevalent MCI; n = 42 had prevalent AD. Results: The proteomic profile yielded an area under the curve (AUC) of 0.92, sensitivity (SN) = 0.80, and specificity (SP) = 0.98 detecting prevalent MCI. For detecting prevalent AD, the proteomic profile yielded an AUC of 0.89, SN = 0.81, and SP = 0.97. The overall profile closely resembled our previously published profile of AD in the general population. Discussion: These data provide evidence of the applicability of our blood-based algorithm for detecting MCI/AD among adults with DS.",
keywords = "Alzheimer's disease, Down syndrome, biomarkers, blood based, plasma",
author = "Melissa Petersen and Fan Zhang and Krinsky-McHale, {Sharon J.} and Wayne Silverman and Lee, {Joseph H.} and Deborah Pang and James Hall and Nicole Schupf and O'Bryant, {Sid E.}",
note = "Funding Information: This work was supported by National Institutes of Health grants; P01 HD035897, U54 HD079123, U01 AG051412 and R01 AG014673, by grant IIRG‐08‐90655 from the Alzheimer's Association as well as by funds from the New York State Office for People with Developmental Disabilities. This work was also supported by the National Institute on Aging by grant R01 AG058537. We thank the study participants and participating agencies from the tri‐state area that made these studies possible. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health from NIA. Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, Inc. on behalf of the Alzheimer's Association.",
year = "2020",
doi = "10.1002/dad2.12023",
language = "English",
volume = "12",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
number = "1",
}