Protein post-translational modifications and regulation of pluripotency in human stem cells

Yu Chieh Wang, Suzanne E. Peterson, Jeanne F. Loring

Research output: Contribution to journalReview article

120 Scopus citations

Abstract

Post-translational modifications (PTMs) are known to be essential mechanisms used by eukaryotic cells to diversify their protein functions and dynamically coordinate their signaling networks. Defects in PTMs have been linked to numerous developmental disorders and human diseases, highlighting the importance of PTMs in maintaining normal cellular states. Human pluripotent stem cells (hPSCs), including embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), are capable of self-renewal and differentiation into a variety of functional somatic cells; these cells hold a great promise for the advancement of biomedical research and clinical therapy. The mechanisms underlying cellular pluripotency in human cells have been extensively explored in the past decade. In addition to the vast amount of knowledge obtained from the genetic and transcriptional research in hPSCs, there is a rapidly growing interest in the stem cell biology field to examine pluripotency at the protein and PTM level. This review addresses recent progress toward understanding the role of PTMs (glycosylation, phosphorylation, acetylation and methylation) in the regulation of cellular pluripotency.

Original languageEnglish
Pages (from-to)143-160
Number of pages18
JournalCell Research
Volume24
Issue number2
DOIs
StatePublished - 1 Feb 2014

Keywords

  • Post-translational modifications
  • hESCs
  • hiPSCs
  • pluripotency-associated signaling

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