Protein kinase Cε makes the life and death decision

Alakananda Basu, Usha Sivaprasad

Research output: Contribution to journalReview article

125 Scopus citations

Abstract

Cancer is caused by dysregulation in cellular signaling systems that control cell proliferation, differentiation and cell death. Protein kinase C (PKC), a family of serine/threonine kinases, plays an important role in the growth factor signal transduction pathway. PKCε, however, is the only PKCε isozyme that has been considered as an oncogene. It can contribute to malignancy by enhancing cell proliferation or by inhibiting cell death. This review focuses on how PKCε collaborates with other signaling pathways, such as Ras/Raf/ERK and Akt, to regulate cell survival and cell death. We have also discussed how PKCε mediates its antiapoptotic signal by altering the level or function of pro- and antiapoptotic Bcl-2 family members.

Original languageEnglish
Pages (from-to)1633-1642
Number of pages10
JournalCellular Signalling
Volume19
Issue number8
DOIs
StatePublished - Aug 2007

Keywords

  • Akt
  • Apoptosis
  • Bcl-2
  • Bid
  • MAPK
  • PKCε
  • Raf
  • Ras

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