Protective effects of adaptation to hypoxia in experimental Alzheimer's disease

Eugenia B. Manukhina, Anna V. Goryacheva, Maya G. Pshennikova, Igor Yu Malyshev, Robert T. Mallet, H. Fred Downey

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Alzheimer's disease (AD) is characterized by formation of amyloid plaques, intracellular neurofibrillary tangles, and cell death in the brain, resulting in progressive loss of memory and cognitive ability. Efficacy of drugs currently used for prevention and treatment of AD is limited by the fact that each drug influences only a single step of the pathogenesis in AD, and the drugs affect both damaged and normal cells. This is why major attention is now paid to nonpharmacological means that may enhance the adaptive capacity and mobilize the self-defense systems of the body. This chapter focuses on protective effects of adaptation to intermittent hypobaric hypoxia on the memory, brain neurons, and cerebral blood vessels in rats with experimental AD induced by intracerebral injections of beta-amyloid (Aß) and mechanisms of these protective effects. Special attention is paid to intermittent hypobaric hypoxia's ability to limit early stages in AD pathogenesis, such as nitrosative and oxidative stress in brain tissue. Presented data show that adaptation to hypoxia may be a promising approach to prevention and treatment of AD.

Original languageEnglish
Title of host publicationIntermittent Hypoxia and Human Diseases
PublisherSpringer-Verlag London Ltd
Pages155-171
Number of pages17
ISBN (Electronic)9781447129066
ISBN (Print)1447129059, 9781447129059
DOIs
StatePublished - 1 May 2014

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    Manukhina, E. B., Goryacheva, A. V., Pshennikova, M. G., Malyshev, I. Y., Mallet, R. T., & Downey, H. F. (2014). Protective effects of adaptation to hypoxia in experimental Alzheimer's disease. In Intermittent Hypoxia and Human Diseases (pp. 155-171). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2906-6_13