Protective and damaging effects of periodic cerebral hypoxia: The role of nitric oxide

Ye B. Manukhina, Kh F. Dauni, R. T. Mallet, I. Yu Malyshev

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Low oxygen delivery to organs and tissues is one of the most life-threatening situations. Periodic hypoxic episodes may have not only damaging, but also protective effects on the organism depending on how long and intensive this factor is. In both cases an important role is played by changes in the synthesis and metabolism of NO. The direction of NO synthesis and, finally, the direction of periodic hypoxia effect is determined by the regimen of hypoxic impact. The effect of NO depends on its concentration. Both NO excess and deficit are very unfavorable to the organism. Sleep apnea syndrome and pulmonary hypertension are typical examples of NO-dependent damaging effects of periodical hypoxia. NO-dependent protective effects of adaptation to periodic hypoxia are underlied by moderate stimulation of NO synthesis, which provides both compensation for NO deficit and the limitation of its hyperproduction. In turn, NO may increase the expression of other protective factors, which makes adaptive protection more reliable and durable. Understanding the mechanisms of adaptation to hypoxia will help develop new approaches to the prevention of hypoxia and ischemic lesions and the improvement of adaptive abilities of the organism.

Original languageEnglish
Pages (from-to)25-33
Number of pages9
JournalVestnik Rossiiskoi Akademii Meditsinskikh Nauk
Issue number2
StatePublished - 2007


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