Abstract
Purpose. The effects of prostaglandin (PG)F(2α) on the contractile response in the longitudinal and coronal vectors of the isolated rhesus monkey ciliary muscle were studied. Methods. Fresh rhesus monkey ciliary muscle strips from young and middle-aged animals were mounted in an apparatus capable of monitoring contractile force simultaneously in the two vectors. The responses to PGF(2α) were measured and compared to those produced with 1 μM carbachol. Results. PGF(2α) consistently relaxed the carbachol precontracted ciliary muscle in a dose-dependent manner with equal potency and efficacy in both vectors, but it did not alter the tone of muscle strips at resting tension. Conclusions. The relaxation of precontracted ciliary muscle by PGF(2α) may help explain how a single topical dose of this prostanoid increases uveoscleral outflow and antagonizes resting myopia in the living monkey.
| Original language | English |
|---|---|
| Pages (from-to) | 2461-2465 |
| Number of pages | 5 |
| Journal | Investigative Ophthalmology and Visual Science |
| Volume | 36 |
| Issue number | 12 |
| State | Published - 1 Jan 1995 |
Keywords
- Macaca mulatta
- carbachol
- ciliary muscle
- prostaglandin F(2α)