Prostaglandin F(2α) effects on isolated rhesus monkey ciliary muscle

J. F. Poyer, John Cameron Millar, P. L. Kaufman

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Purpose. The effects of prostaglandin (PG)F(2α) on the contractile response in the longitudinal and coronal vectors of the isolated rhesus monkey ciliary muscle were studied. Methods. Fresh rhesus monkey ciliary muscle strips from young and middle-aged animals were mounted in an apparatus capable of monitoring contractile force simultaneously in the two vectors. The responses to PGF(2α) were measured and compared to those produced with 1 μM carbachol. Results. PGF(2α) consistently relaxed the carbachol precontracted ciliary muscle in a dose-dependent manner with equal potency and efficacy in both vectors, but it did not alter the tone of muscle strips at resting tension. Conclusions. The relaxation of precontracted ciliary muscle by PGF(2α) may help explain how a single topical dose of this prostanoid increases uveoscleral outflow and antagonizes resting myopia in the living monkey.

Original languageEnglish
Pages (from-to)2461-2465
Number of pages5
JournalInvestigative Ophthalmology and Visual Science
Volume36
Issue number12
StatePublished - 1 Jan 1995

Keywords

  • Macaca mulatta
  • carbachol
  • ciliary muscle
  • prostaglandin F(2α)

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