Prospective influences of circadian clocks in adipose tissue and metabolism

Jeffrey M. Gimble; Gregory M. Sutton; Bruce A. Bunnell; Andrey A. Ptitsyn; Z. Elizabeth Floyd

doi:10.1038/nrendo.2010.214

Prospective influences of circadian clocks in adipose tissue and metabolism

Jeffrey M. Gimble, Gregory M. Sutton, Bruce A. Bunnell, Andrey A. Ptitsyn, Z. Elizabeth Floyd

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Circadian rhythms make a critical contribution to endocrine functions that involve adipose tissue. These contributions are made at the systemic, organ and stem cell levels. The transcription factors and enzymes responsible for the maintenance of circadian rhythms in adipose depots and other peripheral tissues that are metabolically active have now been identified. Furthermore, the circadian regulation of glucose and lipid metabolism is well-established. Animal and human models provide strong evidence that disturbances in circadian pathways are associated with an increased risk of type 2 diabetes mellitus, obesity and their comorbidities. Thus, circadian mechanisms represent a novel putative target for therapy in patients with metabolic diseases.

Original language	English
Pages (from-to)	98-107
Number of pages	10
Journal	Nature Reviews Endocrinology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1038/nrendo.2010.214
State	Published - Feb 2011

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title = "Prospective influences of circadian clocks in adipose tissue and metabolism",

abstract = "Circadian rhythms make a critical contribution to endocrine functions that involve adipose tissue. These contributions are made at the systemic, organ and stem cell levels. The transcription factors and enzymes responsible for the maintenance of circadian rhythms in adipose depots and other peripheral tissues that are metabolically active have now been identified. Furthermore, the circadian regulation of glucose and lipid metabolism is well-established. Animal and human models provide strong evidence that disturbances in circadian pathways are associated with an increased risk of type 2 diabetes mellitus, obesity and their comorbidities. Thus, circadian mechanisms represent a novel putative target for therapy in patients with metabolic diseases.",

author = "Gimble, {Jeffrey M.} and Sutton, {Gregory M.} and Bunnell, {Bruce A.} and Ptitsyn, {Andrey A.} and Floyd, {Z. Elizabeth}",

note = "Funding Information: The authors wish to thank their colleagues in the Stem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA, and the Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA, USA, for their comments and input; Ms Laura Dallam for editorial and administrative assistance; Dr Xiying wu for assistance in the preparation of figures; and the Pennington Biomedical Research Foundation for funding.",

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doi = "10.1038/nrendo.2010.214",

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AU - Sutton, Gregory M.

AU - Bunnell, Bruce A.

AU - Ptitsyn, Andrey A.

AU - Floyd, Z. Elizabeth

N1 - Funding Information: The authors wish to thank their colleagues in the Stem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA, and the Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA, USA, for their comments and input; Ms Laura Dallam for editorial and administrative assistance; Dr Xiying wu for assistance in the preparation of figures; and the Pennington Biomedical Research Foundation for funding.

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N2 - Circadian rhythms make a critical contribution to endocrine functions that involve adipose tissue. These contributions are made at the systemic, organ and stem cell levels. The transcription factors and enzymes responsible for the maintenance of circadian rhythms in adipose depots and other peripheral tissues that are metabolically active have now been identified. Furthermore, the circadian regulation of glucose and lipid metabolism is well-established. Animal and human models provide strong evidence that disturbances in circadian pathways are associated with an increased risk of type 2 diabetes mellitus, obesity and their comorbidities. Thus, circadian mechanisms represent a novel putative target for therapy in patients with metabolic diseases.

AB - Circadian rhythms make a critical contribution to endocrine functions that involve adipose tissue. These contributions are made at the systemic, organ and stem cell levels. The transcription factors and enzymes responsible for the maintenance of circadian rhythms in adipose depots and other peripheral tissues that are metabolically active have now been identified. Furthermore, the circadian regulation of glucose and lipid metabolism is well-established. Animal and human models provide strong evidence that disturbances in circadian pathways are associated with an increased risk of type 2 diabetes mellitus, obesity and their comorbidities. Thus, circadian mechanisms represent a novel putative target for therapy in patients with metabolic diseases.

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Prospective influences of circadian clocks in adipose tissue and metabolism

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