Properdin factor B in black Type 1 (insulin-dependent) diabetic patients

B. Budowle, P. J. Reitnauer, B. O. Barger, R. C.P. Go, J. M. Roseman, R. T. Acton

Research output: Contribution to journalArticlepeer-review


The properdin factor B(Bf) variant F1 was found in 20% of 70 black patients with Type 1 (insulindependent) diabetes compared with 7.3% of 165 control subjects, yielding a significant relative risk of 3.1. In addition, the BfF allele was negatively associated with Type 1 diabetes among blacks, resulting in a relative risk of 0.4. The data suggest that Type 1 diabetes in black Americans may be partially due to admixture of Caucasoid genes.

Original languageEnglish
Pages (from-to)483-485
Number of pages3
Issue number6
StatePublished - Jun 1982


  • Properdin factor B
  • Type 1 diabetes
  • black Americans


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