Properdin factor B and acute lymphocytic leukemia (ALL)

Bruce Budowle, Ronald T. Acton, Bruce O. Barger, Rebecca Blackstock, William Crist, Rodney C.P. Go, G. Bennett Humphrey, Abdel Ragab, Maryanne Roper, Teresa Vietti, James Dearth

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).

Original languageEnglish
Pages (from-to)2369-2371
Number of pages3
JournalCancer
Volume50
Issue number11
DOIs
StatePublished - 1 Dec 1982

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