Abstract
One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).
Original language | English |
---|---|
Pages (from-to) | 2369-2371 |
Number of pages | 3 |
Journal | Cancer |
Volume | 50 |
Issue number | 11 |
DOIs | |
State | Published - 1 Dec 1982 |