Properdin factor B and acute lymphocytic leukemia (ALL)

Bruce Budowle; Ronald T. Acton; Bruce O. Barger; Rebecca Blackstock; William Crist; Rodney C.P. Go; G. Bennett Humphrey; Abdel Ragab; Maryanne Roper; Teresa Vietti; James Dearth

doi:10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S

Properdin factor B and acute lymphocytic leukemia (ALL)

Bruce Budowle, Ronald T. Acton, Bruce O. Barger, Rebecca Blackstock, William Crist, Rodney C.P. Go, G. Bennett Humphrey, Abdel Ragab, Maryanne Roper, Teresa Vietti, James Dearth

Center for Human ID

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).

Original language	English
Pages (from-to)	2369-2371
Number of pages	3
Journal	Cancer
Volume	50
Issue number	11
DOIs	https://doi.org/10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S
State	Published - 1 Dec 1982

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10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S

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title = "Properdin factor B and acute lymphocytic leukemia (ALL)",

abstract = "One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).",

author = "Bruce Budowle and Acton, {Ronald T.} and Barger, {Bruce O.} and Rebecca Blackstock and William Crist and Go, {Rodney C.P.} and Humphrey, {G. Bennett} and Abdel Ragab and Maryanne Roper and Teresa Vietti and James Dearth",

year = "1982",

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doi = "10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S",

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T1 - Properdin factor B and acute lymphocytic leukemia (ALL)

AU - Budowle, Bruce

AU - Acton, Ronald T.

AU - Barger, Bruce O.

AU - Blackstock, Rebecca

AU - Crist, William

AU - Go, Rodney C.P.

AU - Humphrey, G. Bennett

AU - Ragab, Abdel

AU - Roper, Maryanne

AU - Vietti, Teresa

AU - Dearth, James

PY - 1982/12/1

Y1 - 1982/12/1

N2 - One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).

AB - One hundred‐sixty‐four ALL patients were compared to 545 controls for differences in phenotype and gene frequencies at the Properdin factor B locus. In addition, 90 of the ALL patients were immune phenotyped. A significant association with the Bf F allele and ALL was found, resulting in an estimated relative risk of 3.62. There was no difference in the Bf S phenotype between ALL patients and controls. However, those homozygous for the Bf S allele are at a significantly low risk of 0.30 for developing ALL. ALL patients with a non‐B/T cell type were 2.5 times more likely to be Bf SS homozygotes; in contrast, those patients with the pre‐B cell type were 2.5 more likely to be Bf FF homozygotes. These data suggest association of the Bf locus with an ALL protection and/or susceptibility gene(s).

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U2 - 10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S

DO - 10.1002/1097-0142(19821201)50:11<2369::AID-CNCR2820501123>3.0.CO;2-S

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SN - 0008-543X

VL - 50

SP - 2369

EP - 2371

JO - Cancer

JF - Cancer

IS - 11

ER -

Properdin factor B and acute lymphocytic leukemia (ALL)

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