Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia

D. L. Williams, A. Tsiatis, G. M. Brodeur, A. T. Look, S. L. Melvin, Paul Bowman, D. K. Kalwinsky, G. Rivera, G. V. Dahl

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Leukemia cell karyotypes were determined at diagnosis for 136 of 159 consecutive patients with acute lymphoblastic leukemia (ALL) who were followed for up to 35 mo. Ninety patients (67%) had abnormal karyotypes. Five chromosome categories were designated, based on the distribution of modal numbers: hyperdiploid >50 (n = 41), hyperdiploid 47-50 (n = 18), pseudodiploid (n = 28), normal (n = 46), and hypodiploid (n = 3). Treatment response was assessed for the categories in terms to failure (induction failure, first relapse, or death). Children in the hyperdiploid >50 category had the best responses to treatment, with only 2 failures, and those in the pseudodiploid category had the poorest (p < 0.001). The remaining 3 chromosome categories had intermediate responses and formed a third prognostic group. This same influence of chromosome number on time to failure was evident within the 2 clinical prognostic groups: high risk, signified by a leukocyte count >100 x 109/liter, meningeal leukemia mediastinal mass, or the presence of blasts that formed rosettes with sheep erythrocytes at 37°C, and standard risk, indicated by the absence of these features. The influence of chromosome number on time to failure was also the same within the historically favorable prognostic group that had common ALL. Results of a multivariate analysis indicated that chromosome number was the strongest single predictor of outcome (p <0.001) and was the only variable that added significant prognostic information to leukocyte count (p < 0.001). The combination of chromosome number and leukocyte count should more clearly distinguish patients with ALL at low or high risk of relapse.

Original languageEnglish
Pages (from-to)864-871
Number of pages8
JournalBlood
Volume60
Issue number4
StatePublished - 17 Dec 1982

Fingerprint

Chromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Polyploidy
Leukocyte Count
Leukemia
Abnormal Karyotype
Recurrence
Karyotype
Sheep
Multivariate Analysis
Erythrocytes
Therapeutics

Cite this

Williams, D. L., Tsiatis, A., Brodeur, G. M., Look, A. T., Melvin, S. L., Bowman, P., ... Dahl, G. V. (1982). Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. Blood, 60(4), 864-871.
Williams, D. L. ; Tsiatis, A. ; Brodeur, G. M. ; Look, A. T. ; Melvin, S. L. ; Bowman, Paul ; Kalwinsky, D. K. ; Rivera, G. ; Dahl, G. V. / Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. In: Blood. 1982 ; Vol. 60, No. 4. pp. 864-871.
@article{53723003b79a446fb2c860088c680619,
title = "Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia",
abstract = "Leukemia cell karyotypes were determined at diagnosis for 136 of 159 consecutive patients with acute lymphoblastic leukemia (ALL) who were followed for up to 35 mo. Ninety patients (67{\%}) had abnormal karyotypes. Five chromosome categories were designated, based on the distribution of modal numbers: hyperdiploid >50 (n = 41), hyperdiploid 47-50 (n = 18), pseudodiploid (n = 28), normal (n = 46), and hypodiploid (n = 3). Treatment response was assessed for the categories in terms to failure (induction failure, first relapse, or death). Children in the hyperdiploid >50 category had the best responses to treatment, with only 2 failures, and those in the pseudodiploid category had the poorest (p < 0.001). The remaining 3 chromosome categories had intermediate responses and formed a third prognostic group. This same influence of chromosome number on time to failure was evident within the 2 clinical prognostic groups: high risk, signified by a leukocyte count >100 x 109/liter, meningeal leukemia mediastinal mass, or the presence of blasts that formed rosettes with sheep erythrocytes at 37°C, and standard risk, indicated by the absence of these features. The influence of chromosome number on time to failure was also the same within the historically favorable prognostic group that had common ALL. Results of a multivariate analysis indicated that chromosome number was the strongest single predictor of outcome (p <0.001) and was the only variable that added significant prognostic information to leukocyte count (p < 0.001). The combination of chromosome number and leukocyte count should more clearly distinguish patients with ALL at low or high risk of relapse.",
author = "Williams, {D. L.} and A. Tsiatis and Brodeur, {G. M.} and Look, {A. T.} and Melvin, {S. L.} and Paul Bowman and Kalwinsky, {D. K.} and G. Rivera and Dahl, {G. V.}",
year = "1982",
month = "12",
day = "17",
language = "English",
volume = "60",
pages = "864--871",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "4",

}

Williams, DL, Tsiatis, A, Brodeur, GM, Look, AT, Melvin, SL, Bowman, P, Kalwinsky, DK, Rivera, G & Dahl, GV 1982, 'Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia', Blood, vol. 60, no. 4, pp. 864-871.

Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. / Williams, D. L.; Tsiatis, A.; Brodeur, G. M.; Look, A. T.; Melvin, S. L.; Bowman, Paul; Kalwinsky, D. K.; Rivera, G.; Dahl, G. V.

In: Blood, Vol. 60, No. 4, 17.12.1982, p. 864-871.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia

AU - Williams, D. L.

AU - Tsiatis, A.

AU - Brodeur, G. M.

AU - Look, A. T.

AU - Melvin, S. L.

AU - Bowman, Paul

AU - Kalwinsky, D. K.

AU - Rivera, G.

AU - Dahl, G. V.

PY - 1982/12/17

Y1 - 1982/12/17

N2 - Leukemia cell karyotypes were determined at diagnosis for 136 of 159 consecutive patients with acute lymphoblastic leukemia (ALL) who were followed for up to 35 mo. Ninety patients (67%) had abnormal karyotypes. Five chromosome categories were designated, based on the distribution of modal numbers: hyperdiploid >50 (n = 41), hyperdiploid 47-50 (n = 18), pseudodiploid (n = 28), normal (n = 46), and hypodiploid (n = 3). Treatment response was assessed for the categories in terms to failure (induction failure, first relapse, or death). Children in the hyperdiploid >50 category had the best responses to treatment, with only 2 failures, and those in the pseudodiploid category had the poorest (p < 0.001). The remaining 3 chromosome categories had intermediate responses and formed a third prognostic group. This same influence of chromosome number on time to failure was evident within the 2 clinical prognostic groups: high risk, signified by a leukocyte count >100 x 109/liter, meningeal leukemia mediastinal mass, or the presence of blasts that formed rosettes with sheep erythrocytes at 37°C, and standard risk, indicated by the absence of these features. The influence of chromosome number on time to failure was also the same within the historically favorable prognostic group that had common ALL. Results of a multivariate analysis indicated that chromosome number was the strongest single predictor of outcome (p <0.001) and was the only variable that added significant prognostic information to leukocyte count (p < 0.001). The combination of chromosome number and leukocyte count should more clearly distinguish patients with ALL at low or high risk of relapse.

AB - Leukemia cell karyotypes were determined at diagnosis for 136 of 159 consecutive patients with acute lymphoblastic leukemia (ALL) who were followed for up to 35 mo. Ninety patients (67%) had abnormal karyotypes. Five chromosome categories were designated, based on the distribution of modal numbers: hyperdiploid >50 (n = 41), hyperdiploid 47-50 (n = 18), pseudodiploid (n = 28), normal (n = 46), and hypodiploid (n = 3). Treatment response was assessed for the categories in terms to failure (induction failure, first relapse, or death). Children in the hyperdiploid >50 category had the best responses to treatment, with only 2 failures, and those in the pseudodiploid category had the poorest (p < 0.001). The remaining 3 chromosome categories had intermediate responses and formed a third prognostic group. This same influence of chromosome number on time to failure was evident within the 2 clinical prognostic groups: high risk, signified by a leukocyte count >100 x 109/liter, meningeal leukemia mediastinal mass, or the presence of blasts that formed rosettes with sheep erythrocytes at 37°C, and standard risk, indicated by the absence of these features. The influence of chromosome number on time to failure was also the same within the historically favorable prognostic group that had common ALL. Results of a multivariate analysis indicated that chromosome number was the strongest single predictor of outcome (p <0.001) and was the only variable that added significant prognostic information to leukocyte count (p < 0.001). The combination of chromosome number and leukocyte count should more clearly distinguish patients with ALL at low or high risk of relapse.

UR - http://www.scopus.com/inward/record.url?scp=0019906269&partnerID=8YFLogxK

M3 - Article

C2 - 6956375

AN - SCOPUS:0019906269

VL - 60

SP - 864

EP - 871

JO - Blood

JF - Blood

SN - 0006-4971

IS - 4

ER -

Williams DL, Tsiatis A, Brodeur GM, Look AT, Melvin SL, Bowman P et al. Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia. Blood. 1982 Dec 17;60(4):864-871.