Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy

Seth E. Karol, Elaine Coustan-Smith, Xueyuan Cao, Sheila A. Shurtleff, Susana C. Raimondi, John K. Choi, Raul C. Ribeiro, Gary V. Dahl, William Paul Bowman, Jeffrey W. Taub, Barbara Degar, Wing Leung, James R. Downing, Ching Hon Pui, Jeffrey E. Rubnitz, Dario Campana, Hiroto Inaba

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated.

Original languageEnglish
Pages (from-to)94-101
Number of pages8
JournalBritish Journal of Haematology
Volume168
Issue number1
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Remission Induction
Residual Neoplasm
Acute Myeloid Leukemia
Leukemia, Megakaryoblastic, Acute
Therapeutics
Recurrence
Gene Rearrangement
Cohort Studies
Demography
Population

Keywords

  • Acute myeloid leukaemia
  • Minimal residual disease
  • Paediatric
  • Prognostic factor

Cite this

Karol, S. E., Coustan-Smith, E., Cao, X., Shurtleff, S. A., Raimondi, S. C., Choi, J. K., ... Inaba, H. (2015). Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. British Journal of Haematology, 168(1), 94-101. https://doi.org/10.1111/bjh.13107
Karol, Seth E. ; Coustan-Smith, Elaine ; Cao, Xueyuan ; Shurtleff, Sheila A. ; Raimondi, Susana C. ; Choi, John K. ; Ribeiro, Raul C. ; Dahl, Gary V. ; Bowman, William Paul ; Taub, Jeffrey W. ; Degar, Barbara ; Leung, Wing ; Downing, James R. ; Pui, Ching Hon ; Rubnitz, Jeffrey E. ; Campana, Dario ; Inaba, Hiroto. / Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. In: British Journal of Haematology. 2015 ; Vol. 168, No. 1. pp. 94-101.
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abstract = "Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated.",
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Karol, SE, Coustan-Smith, E, Cao, X, Shurtleff, SA, Raimondi, SC, Choi, JK, Ribeiro, RC, Dahl, GV, Bowman, WP, Taub, JW, Degar, B, Leung, W, Downing, JR, Pui, CH, Rubnitz, JE, Campana, D & Inaba, H 2015, 'Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy', British Journal of Haematology, vol. 168, no. 1, pp. 94-101. https://doi.org/10.1111/bjh.13107

Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy. / Karol, Seth E.; Coustan-Smith, Elaine; Cao, Xueyuan; Shurtleff, Sheila A.; Raimondi, Susana C.; Choi, John K.; Ribeiro, Raul C.; Dahl, Gary V.; Bowman, William Paul; Taub, Jeffrey W.; Degar, Barbara; Leung, Wing; Downing, James R.; Pui, Ching Hon; Rubnitz, Jeffrey E.; Campana, Dario; Inaba, Hiroto.

In: British Journal of Haematology, Vol. 168, No. 1, 01.01.2015, p. 94-101.

Research output: Contribution to journalArticle

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T1 - Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy

AU - Karol, Seth E.

AU - Coustan-Smith, Elaine

AU - Cao, Xueyuan

AU - Shurtleff, Sheila A.

AU - Raimondi, Susana C.

AU - Choi, John K.

AU - Ribeiro, Raul C.

AU - Dahl, Gary V.

AU - Bowman, William Paul

AU - Taub, Jeffrey W.

AU - Degar, Barbara

AU - Leung, Wing

AU - Downing, James R.

AU - Pui, Ching Hon

AU - Rubnitz, Jeffrey E.

AU - Campana, Dario

AU - Inaba, Hiroto

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AB - Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated.

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