Abstract
Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated.
Original language | English |
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Pages (from-to) | 94-101 |
Number of pages | 8 |
Journal | British Journal of Haematology |
Volume | 168 |
Issue number | 1 |
DOIs | |
State | Published - 1 Jan 2015 |
Keywords
- Acute myeloid leukaemia
- Minimal residual disease
- Paediatric
- Prognostic factor