Production of interleukin-18 in human tuberculosis

Ramakrishna Vankayalapati, Benjamin Wizel, Stephen Weis, Buka Samten, William M. Girard, Peter F. Barnes

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

To investigate the role of interleukin (IL)-18 in human tuberculosis, IL-18 production was evaluated in blood and at the site of disease in patients with tuberculosis. Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells (PBMC) from tuberculosis patients secreted less IL-18 and interferon-γ (IFN-γ) than did PBMC from healthy persons reactive to tuberculin. M. tuberculosis-induced IFN-γ production was inhibited by anti- IL-18 and enhanced by recombinant IL-18. Alveolar macrophages secreted IL-18 in response to M. tuberculosis, and IL-18 and IFN-γ concentrations were higher in pleural fluid of patients with tuberculosis than in pleural fluid of patients with nontuberculous diseases. These findings demonstrate that IL- 18 production by PBMC correlates with IFN-γ production and effective immunity to tuberculosis, suggesting that IL-18 contributes to a protective type 1 cytokine response in persons with mycobacterial infection.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalJournal of Infectious Diseases
Volume182
Issue number1
DOIs
StatePublished - 12 Aug 2000

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Interleukin-18
Tuberculosis
Interferons
Mycobacterium tuberculosis
Blood Cells
Pleural Tuberculosis
Tuberculin
Alveolar Macrophages
Immunity
Cytokines

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Vankayalapati, R., Wizel, B., Weis, S., Samten, B., Girard, W. M., & Barnes, P. F. (2000). Production of interleukin-18 in human tuberculosis. Journal of Infectious Diseases, 182(1), 234-239. https://doi.org/10.1086/315656
Vankayalapati, Ramakrishna ; Wizel, Benjamin ; Weis, Stephen ; Samten, Buka ; Girard, William M. ; Barnes, Peter F. / Production of interleukin-18 in human tuberculosis. In: Journal of Infectious Diseases. 2000 ; Vol. 182, No. 1. pp. 234-239.
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Vankayalapati, R, Wizel, B, Weis, S, Samten, B, Girard, WM & Barnes, PF 2000, 'Production of interleukin-18 in human tuberculosis', Journal of Infectious Diseases, vol. 182, no. 1, pp. 234-239. https://doi.org/10.1086/315656

Production of interleukin-18 in human tuberculosis. / Vankayalapati, Ramakrishna; Wizel, Benjamin; Weis, Stephen; Samten, Buka; Girard, William M.; Barnes, Peter F.

In: Journal of Infectious Diseases, Vol. 182, No. 1, 12.08.2000, p. 234-239.

Research output: Contribution to journalArticle

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Vankayalapati R, Wizel B, Weis S, Samten B, Girard WM, Barnes PF. Production of interleukin-18 in human tuberculosis. Journal of Infectious Diseases. 2000 Aug 12;182(1):234-239. https://doi.org/10.1086/315656