Principles of ocular pharmacology

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

Recently, in a poll by Research America, a significant number of individuals placed losing their eyesight as having the greatest impact on their lives more so than other conditions, such as limb loss or memory loss. When they were also asked to rank which is the worst disease that could happen to them, blindness was ranked first by African-Americans and second by Caucasians, Hispanics, and Asians. Therefore, understanding the mechanisms of disease progression in the eye is extremely important if we want to make a difference in people’s lives. In addition, developing treatment programs for these various diseases that could affect our eyesight is also critical. One of the most effective treatments we have is in the development of specific drugs that can be used to target various components of the mechanisms that lead to ocular disease. Understanding basic principles of the pharmacology of the eye is important if one seeks to develop effective treatments. As our population ages, the incidence of devastating eye diseases increases. It has been estimated that more than 65 million people suffer from glaucoma worldwide (Quigley and Broman. Br J Ophthalmol 90:262–267, 2006). Add to this the debilitating eye diseases of age-related macular degeneration, diabetic retinopathy, and cataract, the number of people effected exceeds 100 million. This chapter focuses on ocular pharmacology with specific emphasis on basic principles and outlining where in the various ocular sites are drug targets currently in use with effective drugs but also on future drug targets.

Original languageEnglish
Title of host publicationHandbook of Experimental Pharmacology
PublisherSpringer New York LLC
Pages3-30
Number of pages28
DOIs
StatePublished - 1 Jan 2017

Publication series

NameHandbook of Experimental Pharmacology
Volume242
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Fingerprint

Eye Diseases
Pharmacology
Pharmaceutical Preparations
Memory Disorders
Macular Degeneration
Diabetic Retinopathy
Blindness
Hispanic Americans
African Americans
Glaucoma
Cataract
Disease Progression
Therapeutics
Extremities
Incidence
Research
Population
Data storage equipment

Keywords

  • Ocular drugs
  • Ocular pharmacology
  • Pharmacodynamics

Cite this

Park, Y., Ellis, D. Z., Mueller, B., Stankowska, D. L., & Yorio, T. (2017). Principles of ocular pharmacology. In Handbook of Experimental Pharmacology (pp. 3-30). (Handbook of Experimental Pharmacology; Vol. 242). Springer New York LLC. https://doi.org/10.1007/164_2016_25
Park, Yong ; Ellis, Dorette Zoe ; Mueller, Brett ; Stankowska, Dorota Luiza ; Yorio, Thomas. / Principles of ocular pharmacology. Handbook of Experimental Pharmacology. Springer New York LLC, 2017. pp. 3-30 (Handbook of Experimental Pharmacology).
@inbook{b1918f55177e4080a8c1f727aefe1989,
title = "Principles of ocular pharmacology",
abstract = "Recently, in a poll by Research America, a significant number of individuals placed losing their eyesight as having the greatest impact on their lives more so than other conditions, such as limb loss or memory loss. When they were also asked to rank which is the worst disease that could happen to them, blindness was ranked first by African-Americans and second by Caucasians, Hispanics, and Asians. Therefore, understanding the mechanisms of disease progression in the eye is extremely important if we want to make a difference in people’s lives. In addition, developing treatment programs for these various diseases that could affect our eyesight is also critical. One of the most effective treatments we have is in the development of specific drugs that can be used to target various components of the mechanisms that lead to ocular disease. Understanding basic principles of the pharmacology of the eye is important if one seeks to develop effective treatments. As our population ages, the incidence of devastating eye diseases increases. It has been estimated that more than 65 million people suffer from glaucoma worldwide (Quigley and Broman. Br J Ophthalmol 90:262–267, 2006). Add to this the debilitating eye diseases of age-related macular degeneration, diabetic retinopathy, and cataract, the number of people effected exceeds 100 million. This chapter focuses on ocular pharmacology with specific emphasis on basic principles and outlining where in the various ocular sites are drug targets currently in use with effective drugs but also on future drug targets.",
keywords = "Ocular drugs, Ocular pharmacology, Pharmacodynamics",
author = "Yong Park and Ellis, {Dorette Zoe} and Brett Mueller and Stankowska, {Dorota Luiza} and Thomas Yorio",
year = "2017",
month = "1",
day = "1",
doi = "10.1007/164_2016_25",
language = "English",
series = "Handbook of Experimental Pharmacology",
publisher = "Springer New York LLC",
pages = "3--30",
booktitle = "Handbook of Experimental Pharmacology",

}

Park, Y, Ellis, DZ, Mueller, B, Stankowska, DL & Yorio, T 2017, Principles of ocular pharmacology. in Handbook of Experimental Pharmacology. Handbook of Experimental Pharmacology, vol. 242, Springer New York LLC, pp. 3-30. https://doi.org/10.1007/164_2016_25

Principles of ocular pharmacology. / Park, Yong; Ellis, Dorette Zoe; Mueller, Brett; Stankowska, Dorota Luiza; Yorio, Thomas.

Handbook of Experimental Pharmacology. Springer New York LLC, 2017. p. 3-30 (Handbook of Experimental Pharmacology; Vol. 242).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

TY - CHAP

T1 - Principles of ocular pharmacology

AU - Park, Yong

AU - Ellis, Dorette Zoe

AU - Mueller, Brett

AU - Stankowska, Dorota Luiza

AU - Yorio, Thomas

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Recently, in a poll by Research America, a significant number of individuals placed losing their eyesight as having the greatest impact on their lives more so than other conditions, such as limb loss or memory loss. When they were also asked to rank which is the worst disease that could happen to them, blindness was ranked first by African-Americans and second by Caucasians, Hispanics, and Asians. Therefore, understanding the mechanisms of disease progression in the eye is extremely important if we want to make a difference in people’s lives. In addition, developing treatment programs for these various diseases that could affect our eyesight is also critical. One of the most effective treatments we have is in the development of specific drugs that can be used to target various components of the mechanisms that lead to ocular disease. Understanding basic principles of the pharmacology of the eye is important if one seeks to develop effective treatments. As our population ages, the incidence of devastating eye diseases increases. It has been estimated that more than 65 million people suffer from glaucoma worldwide (Quigley and Broman. Br J Ophthalmol 90:262–267, 2006). Add to this the debilitating eye diseases of age-related macular degeneration, diabetic retinopathy, and cataract, the number of people effected exceeds 100 million. This chapter focuses on ocular pharmacology with specific emphasis on basic principles and outlining where in the various ocular sites are drug targets currently in use with effective drugs but also on future drug targets.

AB - Recently, in a poll by Research America, a significant number of individuals placed losing their eyesight as having the greatest impact on their lives more so than other conditions, such as limb loss or memory loss. When they were also asked to rank which is the worst disease that could happen to them, blindness was ranked first by African-Americans and second by Caucasians, Hispanics, and Asians. Therefore, understanding the mechanisms of disease progression in the eye is extremely important if we want to make a difference in people’s lives. In addition, developing treatment programs for these various diseases that could affect our eyesight is also critical. One of the most effective treatments we have is in the development of specific drugs that can be used to target various components of the mechanisms that lead to ocular disease. Understanding basic principles of the pharmacology of the eye is important if one seeks to develop effective treatments. As our population ages, the incidence of devastating eye diseases increases. It has been estimated that more than 65 million people suffer from glaucoma worldwide (Quigley and Broman. Br J Ophthalmol 90:262–267, 2006). Add to this the debilitating eye diseases of age-related macular degeneration, diabetic retinopathy, and cataract, the number of people effected exceeds 100 million. This chapter focuses on ocular pharmacology with specific emphasis on basic principles and outlining where in the various ocular sites are drug targets currently in use with effective drugs but also on future drug targets.

KW - Ocular drugs

KW - Ocular pharmacology

KW - Pharmacodynamics

UR - http://www.scopus.com/inward/record.url?scp=85020375840&partnerID=8YFLogxK

U2 - 10.1007/164_2016_25

DO - 10.1007/164_2016_25

M3 - Chapter

T3 - Handbook of Experimental Pharmacology

SP - 3

EP - 30

BT - Handbook of Experimental Pharmacology

PB - Springer New York LLC

ER -

Park Y, Ellis DZ, Mueller B, Stankowska DL, Yorio T. Principles of ocular pharmacology. In Handbook of Experimental Pharmacology. Springer New York LLC. 2017. p. 3-30. (Handbook of Experimental Pharmacology). https://doi.org/10.1007/164_2016_25