TY - JOUR
T1 - Prevalence of obstructive sleep apnea among patients with rheumatoid arthritis and its association with age and body mass index
T2 - A systematic review and meta-analysis
AU - Thakur, Bhaskar
AU - Pathak, Mona
AU - Singh, Pratima
AU - Padhan, Prasanta
N1 - Publisher Copyright:
© 2021 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd
PY - 2021/11
Y1 - 2021/11
N2 - Aim: The study aims to recognize the prevalence and possible risk factors of obstructive sleep apnea among individuals with rheumatoid arthritis (RA). Methods: We searched PubMed, Scopus, EMBASE, and Google scholar for potential studies published before the October 30, 2020. The study characteristics, obstructive sleep apnea (OSA) events, and various types of rheumatic diseases were extracted, and the meta-analysis method was used to pool the estimates. Results: We identified eight studies with 37 285 patients for this meta-analysis. The overall pooled prevalence of OSA was 29.8% (95% confidence interval [CI] 15.2-46.7; I2 = 99.6%) in the patients with RA. Age was higher in RA patients with OSA but this was not significant. Body mass index (BMI) was significantly associated with OSA in the RA population (standardized mean difference 1.08; P = 0.044). Assessment based on the Berlin Questionnaire© for Sleep Apnea resulted in a more precise estimate of OSA prevalence with reduced heterogeneity (prevalence 45.3%; 95% CI 37.4-53.3; I2 = 58.8%). Conclusion: Prevalence of OSA among the RA cohort was 29.8% with significant heterogeneity. However, the prevalence was 45.3% when studies were restricted to the OSA diagnosis based on the Berlin questionnaire with very low heterogeneity. Higher BMI is the principal risk factor of OSA development in RA. Hence, controlling BMI could be a preventive strategy for OSA among RA patients.
AB - Aim: The study aims to recognize the prevalence and possible risk factors of obstructive sleep apnea among individuals with rheumatoid arthritis (RA). Methods: We searched PubMed, Scopus, EMBASE, and Google scholar for potential studies published before the October 30, 2020. The study characteristics, obstructive sleep apnea (OSA) events, and various types of rheumatic diseases were extracted, and the meta-analysis method was used to pool the estimates. Results: We identified eight studies with 37 285 patients for this meta-analysis. The overall pooled prevalence of OSA was 29.8% (95% confidence interval [CI] 15.2-46.7; I2 = 99.6%) in the patients with RA. Age was higher in RA patients with OSA but this was not significant. Body mass index (BMI) was significantly associated with OSA in the RA population (standardized mean difference 1.08; P = 0.044). Assessment based on the Berlin Questionnaire© for Sleep Apnea resulted in a more precise estimate of OSA prevalence with reduced heterogeneity (prevalence 45.3%; 95% CI 37.4-53.3; I2 = 58.8%). Conclusion: Prevalence of OSA among the RA cohort was 29.8% with significant heterogeneity. However, the prevalence was 45.3% when studies were restricted to the OSA diagnosis based on the Berlin questionnaire with very low heterogeneity. Higher BMI is the principal risk factor of OSA development in RA. Hence, controlling BMI could be a preventive strategy for OSA among RA patients.
KW - meta-analysis
KW - obstructive sleep apnea
KW - rheumatoid arthritis
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85110442806&partnerID=8YFLogxK
U2 - 10.1111/1756-185X.14178
DO - 10.1111/1756-185X.14178
M3 - Article
C2 - 34724599
AN - SCOPUS:85110442806
SN - 1756-1841
VL - 24
SP - 1354
EP - 1361
JO - International Journal of Rheumatic Diseases
JF - International Journal of Rheumatic Diseases
IS - 11
ER -