Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic

R. Deka, Z. Durakovic, W. Niu, G. Zhang, R. Karns, N. Smolej-Narancic, S. Missoni, D. Caric, T. Caric, D. Rudan, B. Salzer, Ranajit Chakraborty, P. Rudan

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Metabolic syndrome, a constellation of risk factors associated with cardiovascular disease and Type 2 diabetes, has reached epidemic proportions worldwide. Epidemiological studies in transitional societies will provide insight into the underlying factors that interact in its manifestation.Aims: To estimate the prevalence of metabolic syndrome, provide a comparative analysis of two metabolic syndrome definitions and assess clustering and association of metabolic traits and cardiovascular diseases in an Adriatic island population.Subjects and methods: In a cross-sectional study, data on four anthropometric, blood pressure and 11 biochemical traits were obtained from 1430 adults from the island of Hvar.Results: Prevalence of metabolic syndrome was 25% and 38.5% based on Adult Treatment Panel III and International Diabetes Federation definitions, respectively. Rates of abdominal obesity, elevated blood glucose and hypertension were high. Among the traits not included in the definitions, levels of LDL, total cholesterol and fibrinogen were markedly elevated. The majority of the phenotypes were significantly associated with the syndrome, the strongest being waist circumference.Conclusion: The Croatian islanders are characterized by a high prevalence of metabolic abnormalities. Central obesity is the strongest contributor of the syndrome. With a high prevalence of dyslipidemia and pro-inflammatory factors, the population is at substantial risk for cardiovascular diseases.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalAnnals of Human Biology
Volume39
Issue number1
DOIs
StatePublished - 1 Jan 2012

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Islands
Population
Cardiovascular Diseases
Abdominal Obesity
Metabolic Diseases
Waist Circumference
Dyslipidemias
LDL Cholesterol
Fibrinogen
Type 2 Diabetes Mellitus
Cluster Analysis
Blood Glucose
Epidemiologic Studies
Cross-Sectional Studies
Blood Pressure
Hypertension
Phenotype

Keywords

  • Adriatic island population
  • Cardiovascular disease
  • Metabolic syndrome
  • Obesity

Cite this

Deka, R., Durakovic, Z., Niu, W., Zhang, G., Karns, R., Smolej-Narancic, N., ... Rudan, P. (2012). Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic. Annals of Human Biology, 39(1), 46-53. https://doi.org/10.3109/03014460.2011.637512
Deka, R. ; Durakovic, Z. ; Niu, W. ; Zhang, G. ; Karns, R. ; Smolej-Narancic, N. ; Missoni, S. ; Caric, D. ; Caric, T. ; Rudan, D. ; Salzer, B. ; Chakraborty, Ranajit ; Rudan, P. / Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic. In: Annals of Human Biology. 2012 ; Vol. 39, No. 1. pp. 46-53.
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Deka, R, Durakovic, Z, Niu, W, Zhang, G, Karns, R, Smolej-Narancic, N, Missoni, S, Caric, D, Caric, T, Rudan, D, Salzer, B, Chakraborty, R & Rudan, P 2012, 'Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic', Annals of Human Biology, vol. 39, no. 1, pp. 46-53. https://doi.org/10.3109/03014460.2011.637512

Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic. / Deka, R.; Durakovic, Z.; Niu, W.; Zhang, G.; Karns, R.; Smolej-Narancic, N.; Missoni, S.; Caric, D.; Caric, T.; Rudan, D.; Salzer, B.; Chakraborty, Ranajit; Rudan, P.

In: Annals of Human Biology, Vol. 39, No. 1, 01.01.2012, p. 46-53.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Prevalence of metabolic syndrome and related metabolic traits in an island population of the Adriatic

AU - Deka, R.

AU - Durakovic, Z.

AU - Niu, W.

AU - Zhang, G.

AU - Karns, R.

AU - Smolej-Narancic, N.

AU - Missoni, S.

AU - Caric, D.

AU - Caric, T.

AU - Rudan, D.

AU - Salzer, B.

AU - Chakraborty, Ranajit

AU - Rudan, P.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Background: Metabolic syndrome, a constellation of risk factors associated with cardiovascular disease and Type 2 diabetes, has reached epidemic proportions worldwide. Epidemiological studies in transitional societies will provide insight into the underlying factors that interact in its manifestation.Aims: To estimate the prevalence of metabolic syndrome, provide a comparative analysis of two metabolic syndrome definitions and assess clustering and association of metabolic traits and cardiovascular diseases in an Adriatic island population.Subjects and methods: In a cross-sectional study, data on four anthropometric, blood pressure and 11 biochemical traits were obtained from 1430 adults from the island of Hvar.Results: Prevalence of metabolic syndrome was 25% and 38.5% based on Adult Treatment Panel III and International Diabetes Federation definitions, respectively. Rates of abdominal obesity, elevated blood glucose and hypertension were high. Among the traits not included in the definitions, levels of LDL, total cholesterol and fibrinogen were markedly elevated. The majority of the phenotypes were significantly associated with the syndrome, the strongest being waist circumference.Conclusion: The Croatian islanders are characterized by a high prevalence of metabolic abnormalities. Central obesity is the strongest contributor of the syndrome. With a high prevalence of dyslipidemia and pro-inflammatory factors, the population is at substantial risk for cardiovascular diseases.

AB - Background: Metabolic syndrome, a constellation of risk factors associated with cardiovascular disease and Type 2 diabetes, has reached epidemic proportions worldwide. Epidemiological studies in transitional societies will provide insight into the underlying factors that interact in its manifestation.Aims: To estimate the prevalence of metabolic syndrome, provide a comparative analysis of two metabolic syndrome definitions and assess clustering and association of metabolic traits and cardiovascular diseases in an Adriatic island population.Subjects and methods: In a cross-sectional study, data on four anthropometric, blood pressure and 11 biochemical traits were obtained from 1430 adults from the island of Hvar.Results: Prevalence of metabolic syndrome was 25% and 38.5% based on Adult Treatment Panel III and International Diabetes Federation definitions, respectively. Rates of abdominal obesity, elevated blood glucose and hypertension were high. Among the traits not included in the definitions, levels of LDL, total cholesterol and fibrinogen were markedly elevated. The majority of the phenotypes were significantly associated with the syndrome, the strongest being waist circumference.Conclusion: The Croatian islanders are characterized by a high prevalence of metabolic abnormalities. Central obesity is the strongest contributor of the syndrome. With a high prevalence of dyslipidemia and pro-inflammatory factors, the population is at substantial risk for cardiovascular diseases.

KW - Adriatic island population

KW - Cardiovascular disease

KW - Metabolic syndrome

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