Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India

Sanjeev Sinha, Ashish Agarwal, Kartik Gupta, Dibyakanti Mandal, Mitul Jain, Roger Detels, Karabi Nandy, Michelle A. Devos, S. K. Sharma, N. Manoharan, P. K. Julka, G. K. Rath, Richard F. Ambinder, Ronald T. Mitsuyasu

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2% (n=20; 95% confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9% (n=9; 95% CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin’s lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries.

Original languageEnglish
Pages (from-to)315-320
Number of pages6
JournalCurrent HIV Research
Volume16
Issue number4
DOIs
StatePublished - 1 Jan 2018

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Tertiary Care Centers
India
HIV
Neoplasms
Acquired Immunodeficiency Syndrome
Confidence Intervals
Appetite
Developed Countries
Non-Hodgkin's Lymphoma
HIV Infections
Weight Loss

Keywords

  • AIDS-defining cancer
  • ART
  • Cancer
  • HIV
  • Invasive cervical cancer
  • Non-Hodgkin’s lymphoma

Cite this

Sinha, Sanjeev ; Agarwal, Ashish ; Gupta, Kartik ; Mandal, Dibyakanti ; Jain, Mitul ; Detels, Roger ; Nandy, Karabi ; Devos, Michelle A. ; Sharma, S. K. ; Manoharan, N. ; Julka, P. K. ; Rath, G. K. ; Ambinder, Richard F. ; Mitsuyasu, Ronald T. / Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India. In: Current HIV Research. 2018 ; Vol. 16, No. 4. pp. 315-320.
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title = "Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India",
abstract = "Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2{\%} (n=20; 95{\%} confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9{\%} (n=9; 95{\%} CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin’s lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries.",
keywords = "AIDS-defining cancer, ART, Cancer, HIV, Invasive cervical cancer, Non-Hodgkin’s lymphoma",
author = "Sanjeev Sinha and Ashish Agarwal and Kartik Gupta and Dibyakanti Mandal and Mitul Jain and Roger Detels and Karabi Nandy and Devos, {Michelle A.} and Sharma, {S. K.} and N. Manoharan and Julka, {P. K.} and Rath, {G. K.} and Ambinder, {Richard F.} and Mitsuyasu, {Ronald T.}",
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Sinha, S, Agarwal, A, Gupta, K, Mandal, D, Jain, M, Detels, R, Nandy, K, Devos, MA, Sharma, SK, Manoharan, N, Julka, PK, Rath, GK, Ambinder, RF & Mitsuyasu, RT 2018, 'Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India', Current HIV Research, vol. 16, no. 4, pp. 315-320. https://doi.org/10.2174/1570162X16666181018161616

Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India. / Sinha, Sanjeev; Agarwal, Ashish; Gupta, Kartik; Mandal, Dibyakanti; Jain, Mitul; Detels, Roger; Nandy, Karabi; Devos, Michelle A.; Sharma, S. K.; Manoharan, N.; Julka, P. K.; Rath, G. K.; Ambinder, Richard F.; Mitsuyasu, Ronald T.

In: Current HIV Research, Vol. 16, No. 4, 01.01.2018, p. 315-320.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India

AU - Sinha, Sanjeev

AU - Agarwal, Ashish

AU - Gupta, Kartik

AU - Mandal, Dibyakanti

AU - Jain, Mitul

AU - Detels, Roger

AU - Nandy, Karabi

AU - Devos, Michelle A.

AU - Sharma, S. K.

AU - Manoharan, N.

AU - Julka, P. K.

AU - Rath, G. K.

AU - Ambinder, Richard F.

AU - Mitsuyasu, Ronald T.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2% (n=20; 95% confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9% (n=9; 95% CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin’s lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries.

AB - Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2% (n=20; 95% confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9% (n=9; 95% CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin’s lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries.

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KW - ART

KW - Cancer

KW - HIV

KW - Invasive cervical cancer

KW - Non-Hodgkin’s lymphoma

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JF - Current HIV Research

SN - 1570-162X

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