TY - JOUR
T1 - Prevalence of HIV in patients with malignancy and of Malignancy in HIV patients in a tertiary care center from north India
AU - Sinha, Sanjeev
AU - Agarwal, Ashish
AU - Gupta, Kartik
AU - Mandal, Dibyakanti
AU - Jain, Mitul
AU - Detels, Roger
AU - Nandy, Karabi
AU - Devos, Michelle A.
AU - Sharma, S. K.
AU - Manoharan, N.
AU - Julka, P. K.
AU - Rath, G. K.
AU - Ambinder, Richard F.
AU - Mitsuyasu, Ronald T.
N1 - Funding Information:
This project was supported in part by grants from NIH, USA DHHS/NIH/NCI/OHAM (R21 CA177310) and Indian Council of Medical Research, India; as part of the Indo-US Collaborative Research in HIV program. We thank the entire staff of IRCH and ART center, AIIMS, for their help.
Publisher Copyright:
© 2018 Bentham Science Publishers.
PY - 2018
Y1 - 2018
N2 - Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2% (n=20; 95% confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9% (n=9; 95% CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin’s lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries.
AB - Background and Objectives: People living with HIV/AIDS are at an increased risk of developing cancer. The goals of this study were to obtain data on the prevalence of HIV in the cancer population and vice versa at a major tertiary cancer and HIV center in North India. Methods: This cross-sectional study was conducted over a 3-year period from July 2013 to June 2016, wherein successive HIV positive patients from an anti-retroviral therapy (ART) center were screened for malignancy. Simultaneously, successive cancer patients at the cancer center were screened for HIV. Baseline demographic details, risk factors, and laboratory investigations were obtained for all the patients. Results: Among the 999 HIV-positive patients at the ART center, the prevalence of malignancy was 2% (n=20; 95% confidence interval (CI) 1.13, 2.87). Among the 998 patients with a malignancy, the prevalence of HIV infection was 0.9% (n=9; 95% CI 0.31, 1.49). Weight loss, loss of appetite, and fever were the most common symptoms in patients with HIV and cancer. Among 29 patients with HIV and cancer, AIDS-defining cancer was found in 19 patients; non-Hodgkin’s lymphoma was the most common malignancy reported (n=13). Interpretation and Conclusion: There is a low prevalence of HIV in cancer patients as well as a low prevalence of cancer in HIV patients. AIDS-defining cancers remain much more common than non-AIDS-defining cancers. With the increased coverage of ART, it is expected that non-AIDSdefining cancers will increase, as is evident from data from more developed countries.
KW - AIDS-defining cancer
KW - ART
KW - Cancer
KW - HIV
KW - Invasive cervical cancer
KW - Non-Hodgkin’s lymphoma
UR - http://www.scopus.com/inward/record.url?scp=85060552763&partnerID=8YFLogxK
U2 - 10.2174/1570162X16666181018161616
DO - 10.2174/1570162X16666181018161616
M3 - Article
C2 - 30338741
AN - SCOPUS:85060552763
SN - 1570-162X
VL - 16
SP - 315
EP - 320
JO - Current HIV Research
JF - Current HIV Research
IS - 4
ER -