TY - JOUR
T1 - Prevalence and factors associated with potentially inappropriate medication use in older medicare beneficiaries with cancer
AU - Feng, Xue
AU - Higa, Gerald M.
AU - Safarudin, Fnu
AU - Sambamoorthi, Usha
AU - Chang, Jongwha
N1 - Funding Information:
This project was supported by the American Cancer Society - Mildred & James Woods Sr. Institutional Research Grant, the United States (grant no. IRG-16-143-07-IRG ), who had no role in the design, data collection and analysis, writing, or submission of this manuscript. The authors are also grateful for the support and insight Dr. Xi Tan provided in completing this study. Appendix A
Funding Information:
This project was supported by the American Cancer Society - Mildred & James Woods Sr. Institutional Research Grant, the United States (grant no. IRG-16-143-07-IRG), who had no role in the design, data collection and analysis, writing, or submission of this manuscript. The authors are also grateful for the support and insight Dr. Xi Tan provided in completing this study.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/10
Y1 - 2020/10
N2 - Objective: To assess the factors related to potentially inappropriate medication (PIM) use in elderly patients with cancer, as well as to compare the PIM prevalence in older adults with and without cancer. Methods: Data from the Surveillance, Epidemiology, and End Results-Medicare-linked base (2009–2011) were accessed to conduct a retrospective study comparing patients with cancers of the breast, colon/rectum, and prostate against a matched population of subjects without cancer. PIM use was defined based on the 2015 Beers Criteria and was quantified using prescription claims. Multivariable logistic regression models were used to assess the associations between the patients’ characteristics, clinical factors, and PIM use in patients with cancer based on Beers criteria. Propensity score matching was applied to compare use of PIM in patients with versus without cancer. Results: PIM usage rates in patients with colorectal and breast cancers were significantly higher than non-cancer-bearing adults; the difference in PIM usage rate was not significantly different in the prostate cancer-matched cohort. The prevalence of inappropriate medication use in the three types of cancers evaluated was directly correlated with number of medications prescribed, treatment with chemotherapy, and co-morbid medical problems. Conclusion: Patients diagnosed with cancer were more likely to use PIM compared with their non-cancer counterparts. The updated Beers criteria has the potential to serve as an important tool in geriatric oncology practice but it may still need to take into consideration different cancer types and their respective treatments.
AB - Objective: To assess the factors related to potentially inappropriate medication (PIM) use in elderly patients with cancer, as well as to compare the PIM prevalence in older adults with and without cancer. Methods: Data from the Surveillance, Epidemiology, and End Results-Medicare-linked base (2009–2011) were accessed to conduct a retrospective study comparing patients with cancers of the breast, colon/rectum, and prostate against a matched population of subjects without cancer. PIM use was defined based on the 2015 Beers Criteria and was quantified using prescription claims. Multivariable logistic regression models were used to assess the associations between the patients’ characteristics, clinical factors, and PIM use in patients with cancer based on Beers criteria. Propensity score matching was applied to compare use of PIM in patients with versus without cancer. Results: PIM usage rates in patients with colorectal and breast cancers were significantly higher than non-cancer-bearing adults; the difference in PIM usage rate was not significantly different in the prostate cancer-matched cohort. The prevalence of inappropriate medication use in the three types of cancers evaluated was directly correlated with number of medications prescribed, treatment with chemotherapy, and co-morbid medical problems. Conclusion: Patients diagnosed with cancer were more likely to use PIM compared with their non-cancer counterparts. The updated Beers criteria has the potential to serve as an important tool in geriatric oncology practice but it may still need to take into consideration different cancer types and their respective treatments.
UR - http://www.scopus.com/inward/record.url?scp=85077648540&partnerID=8YFLogxK
U2 - 10.1016/j.sapharm.2019.12.018
DO - 10.1016/j.sapharm.2019.12.018
M3 - Article
C2 - 31926877
AN - SCOPUS:85077648540
SN - 1551-7411
VL - 16
SP - 1459
EP - 1471
JO - Research in Social and Administrative Pharmacy
JF - Research in Social and Administrative Pharmacy
IS - 10
ER -