Prediction of affinities of peptides for calmodulin

Husheng Yan, Aiguo Ni, Liping Liu, Xiaohui Cheng, Binglin He

Research output: Contribution to journalArticle

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Abstract

A simple method has been developed to predict the calmodulin-binding domains of peptides and the affinities of the peptides for calmodulin based on a model for the calmodulin-binding domains of peptides proposed in a previous paper and the literature data of calmodulin-binding peptides. The effects of hydrophobicities, α-helix-forming tendencies, and basicities of peptides on their affinities for calmodulin were studied. Model peptides were designed to examine the calmodulin-binding domain model and the prediction method. The determined dissociation constants of the complexes formed from the model peptides and calmodulin are in good agreement with the predicted results.

Original languageEnglish
JournalScience in China, Series B: Chemistry
Volume39
Issue number2
StatePublished - 1 Apr 1996

Keywords

  • Binding
  • Calmodulin
  • Peptide

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    Yan, H., Ni, A., Liu, L., Cheng, X., & He, B. (1996). Prediction of affinities of peptides for calmodulin. Science in China, Series B: Chemistry, 39(2).