Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

S. Chandrasekhar; Suchismita Mohapatra; J. S. Yadav

doi:10.1016/S0040-4020(99)00148-9

Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

S. Chandrasekhar, Suchismita Mohapatra, J. S. Yadav

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.

Original language	English
Pages (from-to)	4763-4768
Number of pages	6
Journal	Tetrahedron
Volume	55
Issue number	15
DOIs	https://doi.org/10.1016/S0040-4020(99)00148-9
State	Published - 9 Apr 1999

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title = "Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren",

abstract = "Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.",

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AU - Chandrasekhar, S.

AU - Mohapatra, Suchismita

AU - Yadav, J. S.

PY - 1999/4/9

Y1 - 1999/4/9

N2 - Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.

AB - Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.

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U2 - 10.1016/S0040-4020(99)00148-9

DO - 10.1016/S0040-4020(99)00148-9

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EP - 4768

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 15

ER -

Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

Abstract

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