Practical synthesis of Abbott amino-diol: A core unit of the potent renin inhibitor Zankiren

S. Chandrasekhar, Suchismita Acharya, J. S. Yadav

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Abbott amino-diol (2S,3R,4S)-2-amino-1-cyclohexyl-6-methyl heptane-3,4- diol 1, a main structural constituent of the orally active renin inhibitor Zankiren has been synthesized using Sharpless asymmetric aminohydroxylation as the key step.

Original languageEnglish
Pages (from-to)4763-4768
Number of pages6
JournalTetrahedron
Volume55
Issue number15
DOIs
StatePublished - 9 Apr 1999

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