Potentiation of locomotor activity by d-amphetamine in infant Swiss-Webster mice

Michael J. Forster, Z. Michael Nagy

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Swiss-Webster mice were tested for locomotor activity in either an electromagnetic field (5, 7, or 9 days of age) or photocell shuttle (9, 11, or 13 days of age) apparatus over a 4-h period following systematic injections of d-amphetamine or saline. While d-amphetamine reliably increased activity at all ages tested, the magnitude of the increase varied both as a function of age and apparatus, with younger mice showing a smaller increment than older mice in each apparatus and the electromagnetic field showing relatively greater increments than the photocell apparatus. In addition, amphetamine-induced hyperactivity for the age groups tested was always of longer duration than that reported for adult mice and rats, regardless of the type of apparatus. The present findings for mice are consistent with those that demonstrated that rats respond to amphetamine at early ages and also indicate that both species show similar age differences in the temporal effects of systematically administered amphetamine.

Original languageEnglish
Pages (from-to)278-282
Number of pages5
JournalPhysiological Psychology
Volume11
Issue number4
DOIs
StatePublished - Dec 1983

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