Potentiation of glutamate-activated currents in isolated hippocampal neurons

Yuri I. Zilberter, Vladimir V. Uteshev, Svetlana N. Sokolova, Leonid G. Motin, Haikaz H. Eremjan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


"Fast chemical stimulation" was shown to induce potentiation of glutamate-activated currents in neurons isolated from rat hippocampus. A fast application system allowed solution changes up to a rate of 20 Hz. In Mg2+-free solution, the response to glutamate application immediately after repetitive stimulation with glutamate plus glycine was increased by 25%-88%, returning to control levels over 10-15 min. Enhancement of glutamate-induced currents was also seen after stimulation with solutions containing aspartate or NMDA plus glycine. Aspartate-induced currents were not potentiated. These and other observations demonstrate that in a purely "postsynaptic" system, short-term potentiation can be induced and is mediated via NMDA receptors whereas the potentiated current is carried via non-NMDA glutamate receptor channels.

Original languageEnglish
Pages (from-to)597-602
Number of pages6
Issue number5
StatePublished - Nov 1990


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