Potentiation of amphetamine-induced hyperactivity in the adult mouse following neonatal thyroxine administration

Michael J. Forster, Z. Michael Nagy, James M. Murphy

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

In order to examine possible long-term effects of neonatal hyperthyroidism on catecholamine (CA) neural systems, mice receiving saline or thyroxine injections during the neonatal period were subsequently injected with d-amphetamine or saline immediately prior to testing for locomotor activity at 100 days of age. Thyroxine-treated males were more active than control males following amphetamine injections, but thyroxine-treated and control females did not differ in this regard. In general, the results suggest that neonatal hyperthyroidism may have long-lasting effects on CA function that, at least at the age tested, may be limited to the male mouse.

Original languageEnglish
Pages (from-to)337-339
Number of pages3
JournalBulletin of the Psychonomic Society
Volume18
Issue number6
DOIs
StatePublished - 1 Jan 1981

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