TY - JOUR
T1 - Potential Developmental and Reproductive Impacts of Triclocarban
T2 - A Scoping Review
AU - Rochester, Johanna R.
AU - Bolden, Ashley L.
AU - Pelch, Katherine E.
AU - Kwiatkowski, Carol F.
N1 - Funding Information:
Funding for this work was provided by the Arkansas Community Foundation, Winslow Foundation, Cornell Douglas
Publisher Copyright:
© 2017 Johanna R. Rochester et al.
PY - 2017
Y1 - 2017
N2 - Triclocarban (TCC) is an antimicrobial agent used in personal care products. Although frequently studied with another antimicrobial, triclosan, it is not as well researched, and there are very few reviews of the biological activity of TCC. TCC has been shown to be a possible endocrine disruptor, acting by enhancing the activity of endogenous hormones. TCC has been banned in the US for certain applications; however, many human populations, in and outside the US, exhibit exposure to TCC. Because of the concern of the health effects of TCC, we conducted a scoping review in order to map the current body of literature on the endocrine, reproductive, and developmental effects of TCC. The aim of this scoping review was to identify possible endpoints for future systematic review and to make recommendations for future research. A search of the literature until August 2017 yielded 32 relevant studies in humans, rodents, fish, invertebrates, and in vitro. Based on the robustness of the literature in all three evidence streams (human, animal, and in vitro), we identified three endpoints for possible systematic review: estrogenic activity, androgenic activity, and offspring growth. In this review, we describe the body of evidence and make recommendations for future research.
AB - Triclocarban (TCC) is an antimicrobial agent used in personal care products. Although frequently studied with another antimicrobial, triclosan, it is not as well researched, and there are very few reviews of the biological activity of TCC. TCC has been shown to be a possible endocrine disruptor, acting by enhancing the activity of endogenous hormones. TCC has been banned in the US for certain applications; however, many human populations, in and outside the US, exhibit exposure to TCC. Because of the concern of the health effects of TCC, we conducted a scoping review in order to map the current body of literature on the endocrine, reproductive, and developmental effects of TCC. The aim of this scoping review was to identify possible endpoints for future systematic review and to make recommendations for future research. A search of the literature until August 2017 yielded 32 relevant studies in humans, rodents, fish, invertebrates, and in vitro. Based on the robustness of the literature in all three evidence streams (human, animal, and in vitro), we identified three endpoints for possible systematic review: estrogenic activity, androgenic activity, and offspring growth. In this review, we describe the body of evidence and make recommendations for future research.
UR - http://www.scopus.com/inward/record.url?scp=85039062319&partnerID=8YFLogxK
U2 - 10.1155/2017/9679738
DO - 10.1155/2017/9679738
M3 - Review article
AN - SCOPUS:85039062319
SN - 1687-8191
VL - 2017
JO - Journal of Toxicology
JF - Journal of Toxicology
M1 - 9679738
ER -