Potential application for mesenchymal stem cells in the treatment of cardiovascular diseases

Bruce A. Bunnell; Weiwen Deng; Christine M. Robinson; Paul R. Waldron; Trinity J. Bivalacqua; Syed R. Baber; Albert L. Hyman; Philip J. Kadowitz

doi:10.1139/y05-043

Potential application for mesenchymal stem cells in the treatment of cardiovascular diseases

Bruce A. Bunnell, Weiwen Deng, Christine M. Robinson, Paul R. Waldron, Trinity J. Bivalacqua, Syed R. Baber, Albert L. Hyman, Philip J. Kadowitz

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Stem cells isolated from various sources have been shown to vary in their differentiation capacity or pluripotentiality. Two groups of stem cells, embryonic and adult stem cells, may be capable of differentiating into any desired tissue or cell type, which offers hope for the development of therapeutic applications for a large number of disorders. However, major limitations with the use of embryonic stem cells for human disease have led researchers to focus on adult stem cells as therapeutic agents. Investigators have begun to examine postnatal sources of pluripotent stem cells, such as bone marrow stroma or adipose tissue, as sources of mesenchymal stem cells. The following review focuses on recent research on the use of stem cells for the treatment of cardiovascular and pulmonary diseases and the future application of mesenchymal stem cells for the treatment of a variety of cardiovascular disorders.

Original language	English
Pages (from-to)	529-539
Number of pages	11
Journal	Canadian Journal of Physiology and Pharmacology
Volume	83
Issue number	7
DOIs	https://doi.org/10.1139/y05-043
State	Published - Jul 2005

Keywords

CGRP
Gene therapy
Stem cells
eNOS

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title = "Potential application for mesenchymal stem cells in the treatment of cardiovascular diseases",

abstract = "Stem cells isolated from various sources have been shown to vary in their differentiation capacity or pluripotentiality. Two groups of stem cells, embryonic and adult stem cells, may be capable of differentiating into any desired tissue or cell type, which offers hope for the development of therapeutic applications for a large number of disorders. However, major limitations with the use of embryonic stem cells for human disease have led researchers to focus on adult stem cells as therapeutic agents. Investigators have begun to examine postnatal sources of pluripotent stem cells, such as bone marrow stroma or adipose tissue, as sources of mesenchymal stem cells. The following review focuses on recent research on the use of stem cells for the treatment of cardiovascular and pulmonary diseases and the future application of mesenchymal stem cells for the treatment of a variety of cardiovascular disorders.",

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author = "Bunnell, {Bruce A.} and Weiwen Deng and Robinson, {Christine M.} and Waldron, {Paul R.} and Bivalacqua, {Trinity J.} and Baber, {Syed R.} and Hyman, {Albert L.} and Kadowitz, {Philip J.}",

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AU - Bunnell, Bruce A.

AU - Deng, Weiwen

AU - Robinson, Christine M.

AU - Waldron, Paul R.

AU - Bivalacqua, Trinity J.

AU - Baber, Syed R.

AU - Hyman, Albert L.

AU - Kadowitz, Philip J.

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AB - Stem cells isolated from various sources have been shown to vary in their differentiation capacity or pluripotentiality. Two groups of stem cells, embryonic and adult stem cells, may be capable of differentiating into any desired tissue or cell type, which offers hope for the development of therapeutic applications for a large number of disorders. However, major limitations with the use of embryonic stem cells for human disease have led researchers to focus on adult stem cells as therapeutic agents. Investigators have begun to examine postnatal sources of pluripotent stem cells, such as bone marrow stroma or adipose tissue, as sources of mesenchymal stem cells. The following review focuses on recent research on the use of stem cells for the treatment of cardiovascular and pulmonary diseases and the future application of mesenchymal stem cells for the treatment of a variety of cardiovascular disorders.

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Potential application for mesenchymal stem cells in the treatment of cardiovascular diseases

Abstract

Keywords

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