TY - JOUR
T1 - Posterolateral lumbar spine fusion using a novel demineralized bone matrix
T2 - A controlled case pilot study
AU - Schizas, Constantin
AU - Triantafyllopoulos, Dimitrios
AU - Kosmopoulos, Victor
AU - Tzinieris, Nikos
AU - Stafylas, Kosmas
N1 - Funding Information:
Acknowledgments This study was supported by IsoTis OrthoBiolo-gics Inc., Irvine, CA, USA, in the form of a nonproWt research fund.
PY - 2008/6
Y1 - 2008/6
N2 - Introduction: Intertransverse posterolateral fusion along with instrumentation is a common technique used for spinal fusion. Iliac crest bone graft (ICBG) offers good fusion success rates with a low risk for disease transmission but is, however, linked with certain morbidity. In an effort to eliminate or reduce the amount of iliac graft needed, bone substitutes including demineralized bone matrix (DBM) have been developed. This study evaluates a novel DBM (Accell Connexus®) used in one or two-level instrumented posterolateral lumbar fusion. Materials and methods: A total of 59 consecutive patients were studied as two groups. Group 1 consisted of 33 patients having Accell Connexus® used to augment either ICBG or local decompression material. Group 2 consisted of 26 consecutive patients, operated prior to the introduction of this novel DBM, having either ICBG alone or local decompression material. Fusion was assessed by two independent observers, blinded to graft material, using standardized criteria found in the literature. All adverse events were recorded prospectively. Results: The results show no statistically significant differences between the two groups in fusion rates, complications, surgery duration, ODI, or pain on VAS. Logistical regression showed no relation between fusion and age, smoking status or comorbidities. Furthermore, no adverse events related to the use of the novel DBM were observed. Conclusion: The results from this study demonstrate that the novel DBM presented performs equally as well as that of autologous bone, be it either ICBG or a local decompression material, and can therefore be used as a graft extender.
AB - Introduction: Intertransverse posterolateral fusion along with instrumentation is a common technique used for spinal fusion. Iliac crest bone graft (ICBG) offers good fusion success rates with a low risk for disease transmission but is, however, linked with certain morbidity. In an effort to eliminate or reduce the amount of iliac graft needed, bone substitutes including demineralized bone matrix (DBM) have been developed. This study evaluates a novel DBM (Accell Connexus®) used in one or two-level instrumented posterolateral lumbar fusion. Materials and methods: A total of 59 consecutive patients were studied as two groups. Group 1 consisted of 33 patients having Accell Connexus® used to augment either ICBG or local decompression material. Group 2 consisted of 26 consecutive patients, operated prior to the introduction of this novel DBM, having either ICBG alone or local decompression material. Fusion was assessed by two independent observers, blinded to graft material, using standardized criteria found in the literature. All adverse events were recorded prospectively. Results: The results show no statistically significant differences between the two groups in fusion rates, complications, surgery duration, ODI, or pain on VAS. Logistical regression showed no relation between fusion and age, smoking status or comorbidities. Furthermore, no adverse events related to the use of the novel DBM were observed. Conclusion: The results from this study demonstrate that the novel DBM presented performs equally as well as that of autologous bone, be it either ICBG or a local decompression material, and can therefore be used as a graft extender.
KW - Bone grafting
KW - Demineralized bone matrix (DBM)
KW - Efficacy
KW - Safety
KW - Spinal fusion
UR - http://www.scopus.com/inward/record.url?scp=42549147640&partnerID=8YFLogxK
U2 - 10.1007/s00402-007-0495-4
DO - 10.1007/s00402-007-0495-4
M3 - Article
C2 - 17978826
AN - SCOPUS:42549147640
SN - 0936-8051
VL - 128
SP - 621
EP - 625
JO - Archives of Orthopaedic and Trauma Surgery
JF - Archives of Orthopaedic and Trauma Surgery
IS - 6
ER -